Introducing IN SITU GENOME SEQUENCING, a new technology to resolve DNA sequence🧬 and structure🔬 A team effort with Andrew Payne, Paul Reginato, Ed Boyden, Jason Buenrostro, and Fei Chen science.sciencemag.org/content/early/… This is how it works: (1/8)

I will be writing a review on DNA end resection with Raphael Ceccaldi. If you have a story coming out before the end of the year that you think could be highlighted, please do get in touch.

🧬 Passionate about RNA biology and tackling drug resistance? We are looking for a postdoc to join us. Learn more about the lab and apply: ccr.cancer.gov/staff-director… #PostdocOpportunity #RNABiology #CancerResearch

Job alert! Do you know a postdoc candidate that loves microscopy and wants to visualize how cells repair their DNA, please forward them this opportunity: lumc.nl/en/about-lumc/…

Our paper on continuous mutagenesis in living cells using HACE is now out in Science Magazine! We now demonstrate that HACE continuously generates mutations over a 10-day period and enables targeting using dCas9 without introducing DNA nicks. science.org/doi/10.1126/sc…

We are excited to award the 2024 Basser Global Prize to Patrick Sung, DPhil, of @UTHealthSAMDA for his cutting-edge work in the field of DNA damage repair. He will give the keynote address at our Scientific Symposium in April 2025: spr.ly/6019qQeTU The Sung Lab at UTHSCSA ⁩

📣 Excited to share our latest review on 53BP1’s function in replication stress, its role in fork protection, and the significance of 53BP1 nuclear bodies in this context! sciencedirect.com/science/articl…

Very excited to present the latest preprint from our lab! "FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments" biorxiv.org/content/10.110… .

Excited that our work on transcription-coupled DNA repair is now published Cell! We recapitulated TC-NER in Xenopus egg extract and identified STK19 as a core repair factor that couples stalled Pol II to TFIIH. 🧬🐸 ➡️ cell.com/cell/fulltext/…

New paper with Goran Kokic and Jesper Svejstrup Laboratory in Cell Press! We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair. Great teamwork by diana van den heuvel , Marta Rodríguez-Martínez, Paula van der Meer! cell.com/cell/fulltext/… 1/6

Check out latest from the Walter-Pellman collaboration, revealing how the replisome is remodeled in mitosis to allow CMG eviction, which we propose minimizes fallout from under-replication. biorxiv.org/content/10.110…

Excited to share our preprint reporting a completely new approach to study kinase signaling (ProKAS): "Proteomic Sensors for Quantitative, Multiplexed and Spatial Monitoring of Kinase Signaling" We applied it to DDR kinases. Please share. biorxiv.org/content/10.110…

It's just so tricky to figure out if vaccines work or not Let's look at polio. The data isn't clear We may never know

Interesting finding! Intermittent fasting can cause hair loss Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration: Cell cell.com/cell/fulltext/…

Congratulations to Fernanda Torres on winning Best Female Actor – Motion Picture – Drama at the #GoldenGlobes!

Happy to share our updated opinion on the physiological roles of BRCA1 in this new review: authors.elsevier.com/a/1lDKu3QxxSyl…

Checkout our lab's new publication where we discuss the latest advances in BRCA1 biology at double-strand breaks, including our recent work on how BRCA1 promotes recombination at replication-associated DNA breaks. Kudos to Dali who led this piece! cell.com/trends/cell-bi…

📣New opportunity for #Postdoc researcher!📣 If you are interested in #telomeres and #Cancer, and want to study how TERRA supports survival of ALT cancer cells, don’t miss this chance! Application details at gimm.pt/jobs/postdocto…. Email us ([email protected]) for more info.

Cytarabine has been the mainstay for AML treatment. This chemotherapy can lead to problems with movement and balance. Here we explain this neurotoxic side effect: nature.com/articles/s4158…. Work led by Jia-Cheng Liu, Donpgeng Wang, Elsa Callen and many terrific collaborators!

Only 10 days left to apply! Don't miss this opportunity!