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Brilliant CAR engineering strategy, beautiful data presentation, and compelling storytelling.

I will be in Porto, Portugal, July 4-12, meeting some other science image sleuths, and giving a talk at Universidade Porto. Any journalist or other folks interested in meeting some of us?

Very disappointed to find that Vance Refrigeration is not trending right now.

YES PLEASE

Big Nature paper this week on improved lifespan (in mice!) using an antibody to block IL11 Old mice without IL11 even look healthier 🧵

The 10 biggest medical research papers from this week (in my opinion!) 1. The mTOR inhibitor, Rapamycin, extends lifespan in healthy mice, as does the MEK inhibitor, Trametinib Combining both together boosts mice lifespan by ∼30% biorxiv.org/content/10.110… 🧵

TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules

NaCl enhances CD8+ T cell effector functions in cancer immunotherapy nature.com/articles/s4159…

Yes. CNS are just like the Oscars. It's well know that filmmakers pay the Academy $10b a year to supervise the process, lets voters tell directors to reshoot with a list of 10 new scenes they must add, and the Academy owns the films at the end of the process.

Biggest medical discoveries of the week (🧵) 1/10 Spinal cord injury triggers activation of T cells, inflammation, and death of neurons Editing the T cell receptor, using mRNA, suppressed this, and helped recovery from the injury (in mice!) (Paper: nature.com/articles/s4158…)

Happy to share my co-1st author paper in nature on how the immune system adapts during gender-affirming hormone therapy with testosterone treatment (1/15) nature.com/articles/s4158…

The famous "and then Reagan happened" graph.

There is a major lack of microbial/music parody stickers. Thankfully I'm here to change that! pinkpetri.etsy.com

New human T cell #proteomics data has been added to ImmPRes. The IL2 deprivation is particularly cool, you can see how amino acid transporters drop abundance dramatically after 24h IL2 deprivation.

ImmPressive as always :D

Maybe I'm ignorant of a larger body of work, but MHC-independent TCR stimulation is not something I envisioned. Although diminished, CD4+ T cells develop in MHCII-/- mice, always guessed they might be MHCI restricted, but maybe they're MHC independent? nature.com/articles/s4146…

Meanwhile, in Project 2025 headquarters.

The topic is depressing but this is a stunningly clever bit of data visualisation that addresses a common debate point (total vs per capita emissions)

Still no sign of "turbo cancer", significant #covid19 damage or adverse vaccination effects beyond the expected in #Sweden..... Diagnosis data now to August 2024, so including the peak of this Q3 summer covid wave. 1/

Awwww did someone take your hard work and use it to train a model to mimic your expertise without compensation