🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

We are at #ISMBECCB2023👋 Science & great fun in Lyon! Come say hi & see our posters 📃

Genome Data Science lab - IRB Barcelona is participating in #ISMBECCB2023 !

🧬🔬 Excited to share our new research on #cancer evolution via copy number changes! Work by our👩‍🔬Dr. Liza Besedina: 📚 "Losses of oncogenes and gains of tumor suppressor genes generate common driver events of human cancer" biorxiv.org/content/10.110… 👇

🛑Ignasi's massive mutagenesis study of stop codon readthrough: 5⃣8⃣0⃣0⃣ pathogenic stop codons tested ⚕️cancer + genetic disease 8x💊readthrough drugs 🧬drugs are v differently active depending on genetic context 💻genome-wide predictions! collab Ben Lehner + Genome Data Science lab 💪

🔥Marina's Marina Salvadores Ferreiro study on mutation risk redistribution now out in Nature Cancer We think🤔: disruption in RB1, TP53, &/| higher cell proliferation➡️remodelling of heterochromatin, DNA replication time➡️large-scale changes in mut. accumulation➡️impact on disease genes 👇

Very nice News&Views in Nature Cancer by Xiaoju Hu & Subhajyoti De, covering our Salvadores et al. study on🧬chromatin remodelling and⚡️mutation risk in cancer. 👇 nature.com/articles/s4301…

Excited to share my PhD journey exploring NMD efficiency's variability across tumors, tissues and individuals. Link: biorxiv.org/content/10.110… A big thank you to Fran Supek and the awesome lab Genome Data Science lab at IRB Barcelona 1/7🧵👇

☃️David's paper about mutational coldspots in the human genome is now out in Nucleic Acids Res! Read the latest and greatest version here: academic.oup.com/nar/advance-ar…

🚀 Just published on bioRxiv! 🔍DiffInvex evolutionary model for conditional somatic selection✅ 🧬A genomic study of 10,000 cancer whole genomes identifying chemoresistant genes (putative therapeutic targets)✅ 👨‍💻DiffInvex soon on GitHub⌛️ 📄: biorxiv.org/content/10.110… (1/7) ⬇️

❓Want to learn an easy trick to improve your mutational signatures? ‼️Extract them from SNV and indel mutations jointly! A study by our Patricia F. Patricia Ferrer Torres now online, focusing on HR deficiency signature SBS3🧬 Here is a TL;DR for you 👇 (1/3)

Very excited to have my first preprint published! 🥳 Thanks to Fran Supek and our lab Genome Data Science lab 🧬

🧬asymmetry in the cancer transcriptome? A new preprint by Guillermo Palou Márquez and Pere P from the lab has dropped on biorxiv TLDR: in tumors, allele-specific expression (imbalance between 👩‍💼maternal and 👨‍🔧paternal allele in mRNA levels) is commonly seen in cancer genes... (1/2)

New pre-print out! 👨‍🔬 🔗biorxiv.org/content/10.110… Here, we studied the incidence and impact of allele-specific expression (ASE; imbalance between two alleles in mRNA levels ⚖️) in tumorigenesis. 1/6