Competition for H2A.Z between genes and repetitive elements establishes response to anti-viral immune activation biorxiv.org/cgi/content/sh… #biorxiv_genomic

Thanks Duke Radiation Oncology and David Kirsch, MD, PhD for the incredible support and confidence. The environment Duke Health is optimal for physician-scientist trainees.

Very impressive work! What compensates Dux in mouse ZGA has puzzled me for ~4 years. I generated Obox1/2/5/7 QKO, but failed to see apparent phenotypes. It turns out that Obox4 is the promising one! A big mystery is largely resolved! biorxiv.org/content/10.110…

So humbled and honored to receive this award. Thank you ASTRO for recognizing our work and supporting my physician-scientist aspirations

Thanks Henning Willers, MD, FASTRO for an energizing finish to a great night Duke Radiation Oncology research retreat

Excited to share our work on chromatin landscape remodeling in cloned embryos! 🐄🐄We started off w/ simple question: how does the somatic epigenome reprogram to prepare for the onset of transcription (EGA)? tinyurl.com/yc4wv76p

In SLC for Brad Cairns’ 25th lab anniversary. Was truly a humbling experience to be a part of great science with great scientists. We’ve spanned the gamut from biochemistry of yeast chromatin remodelers, zebrafish epigenome reprogramming, ZGA, and germline stem cells.

Physician-scientists are a dying breed going from 4.7% in '80s to ~1.5% today. Multiple factors contribute including flat/declining #NIH funding. Translational research is critical for advancing clinical care. jamanetwork.com/journals/jaman…

ROI 5k duke crew! #astro2023

(1/5) Our paper on pooled genetic screening of TERT-mutated #glioblastoma is out in Nature Portfolio Oncogene Journal! We analyzed data from 500 #clinical and ~1300 #preclinical samples. Graphical abstract in the thread! nature.com/articles/s4138…

Huge thanks to Conquer Cancer, the ASCO Foundation and quadwfoundation for giving me this opportunity and for funding sarcoma research. Elated to join the growing network of QuadW researchers both near and far.

Your donation dollars in action! 🙌A #StandUpToCancer-funded #research team unveiled an exciting #clinicaltrial breakthrough that reduces risk of #cancer relapse by 43% – for 2 of the most common types of soft tissue #sarcoma in adults, 2 years after treatment. Learn more:

Just in time for #CTOS2024: Thrilled to share SU2C-SARC032 (NCT03092323), a randomized trial of pembrolizumab in Stage 3 extremity soft tissue sarcoma, now published The Lancet! authors.elsevier.com/a/1k5JbV-4XOupH 1/13 SARC Stand Up To Cancer CTOS Radiation Medicine Program Princess Margaret Cancer Centre University Health Network Radiation Oncology