We’re back for the last session of METPHYS2025 and Isha Jain is schooling us on the Goldilocks principle of oxygen availability

Next up at METPHYS2025 Donita Brady is sharing her work concerning how mitochondrial copper homeostasis influences TCA cycle fluxes and nutrient signaling

Next up at METPHYS2025 staying with metals in metabolism Rich Possemato is moving us away from copper and into iron

Last talk before we present the Sable Award at METPHYS2025 is a short talk from Kevin Hicks outlining approaches to define the protein-metabolite interactome and the MIDAS platform

🚨Thrilled to announce the 2nd Denis Richard Intl. Symposium – Nov 21, Quebec City! Theme: The Science of Obesity: From Biology to Behavior Speakers: Prof Lora Heisler, Greg_Steinberg, Philip Schauer, MD, Jens Brüning, Joe Bass, Ruth Loos, Steven Heymsfield & Kelly Allison

Coolest part of this story is Yibin Wang and his group in Singapore have arrived at the same conclusion in parallel Independent co-discovery = reproducible science Stay tuned for the papers from both groups!

Our paper Science Immunology shows certain lipids are responsible for the immunosupression of ascites & propose blocking lipid uptake thru SCARB1 may help immunotherapy success in ovarian cancer. Wonderful to collaborate with Donal Brennan again, Marcia Haigis & super postdoc Karen Slattery

This is interesting, de novo serine biosynthesis is upregulated as an adaptive response during mitochondrial stress cell.com/cell-reports/f…

Online today in nature - our latest study led by superstar postdoc Gilles Rademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s4158… full text available here 👉 rdcu.be/em0VG and thread 👇

FYI - We've extended abstract submission deadline to June 9. Submit soon to be considered for a short talk. Come join us at the first FASEB #Ferroptosis meeting! It's going to be awwwwesome! 🤩 events.faseb.org/event/11797f9e…

Excited to share our latest study from the Manning Lab. We have developed and characterized a novel mouse model lacking the five AKT phosphorylation sites on the TSC2 protein, which are critical for AKT-mediated activation of mTORC1 signaling.

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | New England Journal of Medicine nejm.org/doi/full/10.10…

Huge thanks to all the speakers at ADA2025 for sharing excellent science!! It was so fun to organize these sessions with Paul Titchenell! This one is for you no-social-media-Nav

A cure for type 1 diabetes is literally just around the corner !!!!! Very much understand Dickens today “It was the best of times is was the worst of times” 10 out of 12 don’t need insulin one year post treatment 🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🤯

As promised, a 🧵 on our recent article now out in NatureStructMolBiol! Co-led with Abby Bartlett Pagliarini Lab Judith Simcox PhD, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯#lipidtime doi.org/10.1038/s41594…

My lab’s 5-year NIH R01 grant, awarded to study gene therapy for hearing loss, was abruptly terminated. I want to share how this action has been incredibly harmful and disruptive, not just to my lab, but to the scientific process itself. 1/15

We all know that weight loss in obesity is good- but why does it help? And why is weight regain afterward harmful? 🤔 Excited to announce our new paper is finally out in @JClinicalInvest! 🚀👇 jci.org/articles/view/…

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥

See new job opportunity in our lab. •Collaborate with world-leading industry partner •Join a dynamic team advancing metabolic disease research and shaping the future of obesity treatments unimelb.wd105.myworkdayjobs.com/UoM_External_C…