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Come and visit our poster P06 during the poster sessions at 1st International Symposium on Advances in Phage Therapeutics Azeredo Lab 😊 Our colleague Marco Pardo-Freire will be presenting our phage collection for M. Abscessus and all his work for expanding the host range!

Visit our poster P06 at the 1st International Symposium on Advances in Phage Therapy #Braga2025 Azeredo Lab about mycobacteriophages!! Proud of Marco Pardo-Freire presenting part of his PhD project!! Universitat València CSIC VLC Phage Hunters

Our PhD researcher Mireia Mireia Bernabéu-Gimeno presenting today at 1st International Symposium on Advances in Phage Therapeutics Azeredo Lab the preliminary results of 4 compassionate phage use for M. Abscessus infections using a 6-weeks treatment approach including local administration 💪🏼😊

Proud of Mireia Bernabéu-Gimeno presenting part of her PhD project treating M. abscessus-infected patients with #phage. Thanks to Azeredo Lab for the opportunity to present our work at the 1st Advances in Phage Therapeutics! Universitat València CSIC VLC Phage Hunters Evolving Therapeutics Fed. Esp. Fibrosis Quística

Excited to have joined the 1st International Symposium on Advances in Phage Therapeutics Azeredo Lab with our colleagues from #EnBiVirLab VLC Phage Hunters 🤗 Proud to advance phage therapy for real-world impact💪 Pilar Domingo-Calap Mireia Bernabéu-Gimeno Marco Pardo-Freire #PhageTherapy #Biotech

📢 Very excited to share our latest work on K. pneumoniae resistance to phages! We show that phage resistance can occur through capsule loss in a fast and reversible way in the abscence of mutations! 🦠🧬 biorxiv.org/content/10.110… Pilar Domingo-Calap Sanjuan Lab Thread here!🧵👇🏻

Previous studies showed that Klebsiella evades phage infection by losing or modifying its capsule due to mutations in capsule biosynthesis genes 🧬

In our study, phage infection selected for acapsular variants without any detectable mutations. However, we observed a significant downregulation of capsule related genes via transcriptomics. A non-mutational route to resistance! 🔬📊

Using single-cell assays, we found that once phage pressure was removed, these acapsular cells rapidly restored capsule production regaining sensitivity to phage. A fast and reversible response to phage selective pressure! 🦠🔁

These findings suggest that Klebsiella can resist phages via changes in gene expression, offering a flexible and dynamic alternative to mutation-driven resistance. A new layer of complexity in phage-bacteria interactions!💡🌌

Check out the full story 👉🏻 biorxiv.org/content/10.110… VLC Phage Hunters #phage #Klebsiella #microbiology #capsule

🗓️ | #AgendaPCUV  Evolving Therapeutics, #PCUV startup, will participate next June 25 in the Women TechEU  Matchmaking Event. 🚀  More info ⬇️ b2match.com/e/women-in-dee…

Already available at bioRxiv the results of one of the PhD projects from our colleague LucasMQ 🥰 Valuable insights about K. pneumoniae phage-resistance mechanisms 🧫🙌🏼 Do not miss it! biorxiv.org/content/10.110… Pilar Domingo-Calap Sanjuan Lab

Coming back from enriching 2-days with all our scientific colleagues from the phage therapy field 😊 honored to share the first results of compassionate treatments for M. Abscessus as part of my PhD project 💪🏼 Thanks Pilar Domingo-Calap and Azeredo Lab for the opportunity!

❗Hoy hablamos de las bacterias #ESKAPE 🦠¿Qué son las bacterias ESKAPE y por qué debemos preocuparnos? Dentro hilo!⏬

👩‍🏫Donem l'enhorabona a Pilar Domingo-Calap Evolving Therapeutics per aconseguir la seua plaça de Professora Titular de la Universitat València ⬇️ x.com/VLCphagehunter…

Disfrutando de nuestro retreat de lab celebrando la plaza de profesora titular de Pilar Domingo-Calap 🥰🙌🏼

Phage therapy in a patient with prosthetic join infection in Spain! Another sucessful treatment from the #EnBiVir VLC Phage Hunters Evolving Therapeutics in collaboration with Dr. de la Villa Special mention Mireia Bernabéu-Gimeno and Marco Pardo-Freire for the phage production! sciencedirect.com/science/articl…

🦿Pilar Domingo-Calap Evolving Therapeutics ens parla sobre un tractament exitós en un pacient amb infecció de pròtesi articular ⬇️ x.com/pilardomingoc/…

Today's pre-holiday lab meeting! Happy with the current progress and motivated to continue our research 😊💪🏼🙌🏼