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On bioRxiv today, we raise serious concerns over a recent @nature paper describing ReDeeM, a new single-cell mitochondrial DNA (mtDNA) sequencing / analysis method. Here are three things that you need to know: 1/n biorxiv.org/content/10.110…

ALCmax <0.5 ×103/μL is predictive of nonresponders, whereas that of >1.0 × 103/μL is an independent biomarker for sustained response. ow.ly/rOza50SXHXM #plasmacelldisorders #healthservicesandoutcomes #immunobiologyandimmunotherapy #lymphoidneoplasia

Your body has over 200 lymph nodes, which can be thought of as a first line of defense against pathogens and even metastatic cancer spread. They are "decision structures" carefully composed of a slew of immune cell types acting in careful choreography when the body encounters

📢 This Friday, we’re highlighting the largest spatial & single-cell characterization of Castleman Disease (CD) lymph node samples! 🎉 Congrats to HemepathMD and lab. The study used a 44-plex PhenoCycler panel & single-cell tech to uncover novel cell types & pathways in CD.

“Hunting down the elusive cytosolic-DNA sensor,” by Diane Mathis outlines how cGAS was discovered, and the crucial findings made by Zhijian “James” Chen, winner of the 2024 Basic Research #LaskerAward. pnas.org/doi/10.1073/pn… #Lasker2024 #LaskerLaureate #UTSWMed

Shortly after a patient received CAR T-cell therapy for relapsed CNS lymphoma, an aggressive CAR+ T-cell lymphoma was diagnosed. Subsequent analysis revealed the presence of an abnormal clone in an early apheresis specimen. Read the Brief Report: nej.md/3BuToVM

Think you're doing science right? These 9 rules might shatter everything you believe about research...

Gene therapy is transforming how we treat genetic disorders, but what if mutations in more than 30 genes can cause similar symptoms? Now published in Cell Stem Cell (cell.com/cell-stem-cell…), we report the development of a universal gene therapy for Diamond Blackfan anemia. 1/n

Proud to share our group latest paper in Nature. "Spatial immune scoring system predicts hepatocellular carcinoma recurrence." A game-changer for early-stage HCC management - high risk patients benefited from Immunotherapy - Dawn of Spatial Medicine? nature.com/articles/s4158… Our

#Pediatric Scientist Development Program grant was terminated. The federal grant that has sustained PSDP for over 35 years was abruptly ended with no opportunity for appeal. This is utterly unconscionable if you care about the health of children. amspdc-psdp.org/psdp-advocacy-…

2025 Atlantic Regional HematoPathology Meeting is taking place this week NYU GSOM Pathology in NYC! Don’t miss it! Organized by our own Chris Park, MD/PhD. NYU Grossman School of Medicine #pathology #hemepath #heme

Comparison of severe aplastic anaemia and lower risk hypoplastic myelodysplastic neoplasms: Critical role of megakaryocyte count in distinguishing aplastic anaemia from myelodysplastic neoplasms buff.ly/3x8G0xM

In a landmark scientific feat published in NEJM, a Children's Hospital & Penn Medicine team treated the first patient with personalized #genetherapy, designed uniquely for newborn KJ, who was diagnosed with a rare #ureacycledisorder at birth. Learn more: ms.spr.ly/6016Sw9IC

nature.com/articles/s4146…