Othmane Jadi presenting on mHAs and differences in clinical outcomes for transplant patients mediated by T-cells #pirlsymposium

Dante Bortone presenting a massive reanalysis of different published RNA based predictors of response to checkpoint blockade tl;dr the situation is pretty bad

Dan Van Twisk presenting his work comparing different methods for identifying gene fusions

Presentation by Dhuvi Karthikeyan dhuv.io on immunogenicity prediction Lots of models based on either antigen sequence and/or structure, unclear if any of them out-perform just peptide-MHC affinity in predicting T-cell responses. #pirlsymposium

Second day of #pirlsymposium Panel on high throughput T-cell assays

Next #pirlsymposium panel on overcoming limits of neoantigen vaccination

Next #pirlsymposium panel talking about predicting T-cell responses to peptide/MHC pairs

Seminar at UNC Lineberger by Dr. Chris French about NUT carcinoma, which is an under-studied cancer our lab has recently taken significant interest in.

alex rubinsteyn and Benjamin Vincent speaking on the vision of Personalized Immunotherapy Research Lab: closing the loop on in-silico therapeutic design, in-vitro validation, and translational trials for #personalizedmedicine #immunotherapy

Blog post by dhuv.io: "Defining Immunogenicity for Immunogenicity Prediction" pirl.unc.edu/blog/defining-…

New blog post! "Adventures in mRNA lipid nanoparticle formulation" pirl.unc.edu/blog/adventures

New post by Jin Seok (Andy) Lee: Shaking the Rust Off Python pirl.unc.edu/blog/shaking-t… He tries to speed up parallel nucleotide kmer counting by moving the inner loop from Python to Rust and finds it surprisingly difficult to get more than 3x faster

Another blog post by Jin Seok (Andy) Lee diving deeper into using Rust to speed up Python bioinformatics code (using some recommendations from Michael Lazear and 𝕐 to go 3x faster than our best previous implementation)

Thrilled to announce that our new paper is out at Blood Advances now! Please check out our work on shared minor histocompatibility antigens, including discovery of 24 novel shared mHAs! Done with Benjamin Vincent and Paul Armistead, with Lara Sucheston-Campbell, PhD, MS 🧵ashpublications.org/bloodadvances/…

We have taken a deep interest in NUT carcinoma at Personalized Immunotherapy Research Lab and have a few ideas for how it could be treated (eg therapeutic vaccination targeting NUTM1) Looking for a staff molecular biologist (ideally immunologist) to do some of the preclinical work: unc.peopleadmin.com/postings/250975

Congratulations to Dr. @KOimmuno on successfully defending her PhD! It’s been wonderful having you as a part of PIRL and we're excited to see what you do next!

Thank you to everyone for your support over the years- I am officially PhDone!!!!

Jenny Jiang presenting on the sequence diversity of TCRs for conserved SARS-CoV-2 T-cell epitopes at the UNC TCR Discovery Symposium

Really fascinating talk by Aude Chapuis showing escape from WT1 specific immune pressure by AML through switching proteasome sub-unit expression

Don’t stop pretraining! Or something like that… Excited to be presenting work from Personalized Immunotherapy Research Lab at #MLCB2023. If you’re interested in learning about how a model for few-shot facial recognition from 2015 can help encode semantic similarity between Tcell epitopes, stop by poster143!