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We look at QTLs in dozens of differentiating cell types and dynamic trajectories simultaneously in vitro - check out our new preprint and Josh Popp 's thread! biorxiv.org/content/10.110…

A REALLY cool combination of expertise from the worlds of human genetics and stem cell biology. Many genetic effects on gene expression will only manifest in specific cell states. These iPSC-based cultures feature both diverse cell states AND diverse genetic backgrounds.

Thrilled to share that I am joining the Department of Human Genetics Emory School of Medicine as an Assistant Professor! I was an undergraduate at Emory before, and it's an honor and a privilege to return as faculty. (1/3)

Switching to training transGRNS on perturbation expts with RNAonly read outs will provide some improvements but u still will be training models on misspecified & underspecified inputs, even with "causal" modeling methods. Many issues identified in the paper will continue. 6/

Cell type and dynamic state govern genetic regulation of gene expression in heterogeneous differentiating cultures dlvr.it/TGXTN5

Our study led by Josh Popp is up! Context-specific genetic regulation of gene expression in heterogeneous differentiating cultures.

IMO the defining trait of an enhancer or regulatory element is a change in sequence causing a change in gene expression. Really cool that we can use stem cells to systematically accrue evidence for these effects in new, previously-inaccessible contexts.

Cell type and dynamic state govern genetic regulation of gene expression in heterogeneous differentiating cultures dlvr.it/TGkfP4