Another synthetic lethal target in the recurrent 9p21 deletion observed in many solid cancers, including #glioblastoma and #PancreaticCancer (MTAP being the other one thats being targeted by PRMT5i) Superkiller complex problems expose a cancer-cell vulnerability

I’m proud to share that PanCAN has signed on to this important statement alongside our partners in the cancer community — together, we urge the administration and Congress to prioritize #cancer research funding and protect the progress that saves lives. OVAC

Proud to share our latest work in @nature, co-led by Chadi A. El Farran, Charles Couturier, MD, PhD & Brad Bernstein! We developed a new framework to understand immunomodulatory myeloid cells in #glioma & lay a foundation to develop more effective immunotherapies🧵 nature.com/articles/s4158…

In colorectal cancer, IL-17RA promotes tumors early in tumorigenesis t& later suppresses tumor invasion and metastasis by limiting epithelial-to-mesenchymal transition & stimulating IL-18 secretion cell.com/immunity/fullt… Immunity

A huge missing piece in the public discourse about federal funding at universities is that these are not handouts but are instead used to address challenges that the government considers important for the country and scientific progress. There is a massive disconnect here. 1/5

.Mark Cuban More recent data shows NIH-funded research contributed to 354 of 356 drugs (99.4%) approved from 2010–2019. Public funding is indispensable to the health and betterment of the American people—we must do a better job communicating this.

Published in Immunity, Peter Fecci lab (Duke Neurosurgery), Jan 2025. Tumor-associated macrophages (TAMs), not tumor cells, are primary mediators of progression from progenitor-exhausted to terminally-exhausted T cell state in GBM. TAM-T cell interaction are typically prolonged

Super excited for this amazing work to come out. Honored to have been able to contribute.

Republicans once argued that biomedical research was an engine for economic growth and helped double the NIH budget. It led to countless medical breakthroughs and saved lives. Now, they are proposing to cripple the NIH through massive cuts. Who will have the courage to say no?

In case you didn’t think the brain drain would happen - France and the EU are now actively recruiting US-based scientists disillusioned by funding cuts and political interference by launching a “Choose Europe for Science” campaign.

Anyone who wants to call scientific research “wasteful spending” should have to get past Reviewer 2. Seriously, I wish people knew how hard we work for far less $ than could be made in industry, all because we care about helping society and mentoring the next generation.

If a foreign adversary snuck into our Federal budget and cut science research and education the way we’re cutting it ourselves — strategically undermining America’s long-term health, wealth, and security — we would likely consider it an act of war.

Kicking off the 10th annual Midwest Tumor Microenvironment meeting at the University of Minnesota. #MidwestTME2025 Masonic Cancer Center, University of Minnesota College of Sci & Eng UMN Biomedical Eng UMN H.O.T. Division cancerbioengineering.umn.edu/10th-annual-mi…

Wonderful talk at #MidwestTME2025 from Rebecca Dodd (University of Iowa) on Sarcomas. UI Holden Comprehensive Cancer Center

Amazing Keynote talk from David DeNardo WUSM at the 10th annual Midwest Tumor Microenvironment meeting #MidwestTME2025 Masonic Cancer Center, University of Minnesota Siteman Cancer Center UMN Biomedical Eng UMN H.O.T. Division

8 years ago today we lost our dearest #PatKeely who revolutionized the #TME #ECM field by introducing us to the diagnostic/prognostic tumor-associated collagen signatures #TACs We miss her enormously everyday ❤️‍🩹

Want to get direct quantitative ECM orientation data in histology slides in an easy straightforward way? Check out our new paper on PPM. National Cancer Institute UW LOCI (Eliceiri lab) American Cancer Society sciencedirect.com/science/articl…

Very excited to share our preprint on #AI directed Deep Visual Proteomics (DVP) on #PancreaticCancer precursor lesions (PanINs), in collaboration with OmicVision Andreas Mund Thousands of proteins from as few as ~100 precisely microdissected cells in archival samples!

We are thrilled to announce that Dean Andrew Alleyne has named Professor Jonathan Sachs as Head of the Department of Biomedical Engineering! Sachs joined the University of Minnesota faculty in 2006. Read more: cse.umn.edu/bme/news/jonat…

Excited to see this platform emerge. Great way to directly capture quantitative ECM organization information!