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SARS-CoV-2 reprograms your aging. Three years later, survivors—especially women—show accelerated epigenetic aging across multiple DNA clocks. Core genes involved in fertility, inflammation, and cellular repair were hit. GrimAge, FitAge, SkinBloodClock: all shifting.

Chambers et al. w/Cory Dungan, PhD Boehringer Ingelheim Prof Steve Horvath Clock Foundation UKY Center for Muscle Biology UA Exercise Science UARK Health, Human Performance and Recreation UA COEHP UArkansas Research in Aging Cell Exploring epigenetic aging, senescence, and regeneration in skeletal muscle #myotwitter onlinelibrary.wiley.com/doi/full/10.11…

The first comprehensive analysis of DNAm age difference between EPICv1 and EPICv2 in three commonly used biological samples including buffy coat, PBMC and saliva. #DNAm By Jian Hua Tay,Elena Sandalova, Brian Kennedy, Prof Steve Horvath, et al. nature.com/articles/s4200…

NEW STUDY shows a 5-year increase in the AAGrimAge clock is associated with greater risk of death by: 1. All-causes - 44% 2. Cardiovascular events - 33% 3. Non-Cardiovascular events - 54% So why do these clocks predict disease & death?... 🧵

New study: 📊 GrimAge2 epigenetic clock predicts all-cause & cause-specific mortality better than HorvathAge or HannumAge. Every 5-year increase = ☠️ 40% higher death risk. 🔗…lepigeneticsjournal.biomedcentral.com/articles/10.11… 👏 Thanks to Yun Zou, Jing Huang, Xiaoli Tang, and Jixiong Xu for bringing

NEW STUDY: People who consistently do vigorous exercise have slower rates of epigenetic aging compared to those who don't. Light to medium activities don't cut it tinyurl.com/k552u4my

GrimAge epigenetic clock beats other clocks in predicting mortality in a 1200-person study (avg. age 64). It mediates health exposures like oxidative balance & frailty, making AgeAccelGrim2 a key biomarker for diabetes/pre-diabetes risk stratification. Shuang Wu, Yang Chen 2025.

GrimAge & PhenoAge epigenetic clocks link to functional ability & intrinsic capacity in frail OLDER adults (mean age 84). COGFRAIL study shows significant ties to specific capacity domains despite small sample (n=163). Pedro L Valenzuela, Sandrine Sourdet, Philipe de Souto

🚀 2025 Conference Promotion Kick-off! We’re officially kicking off our promotion for the 2025 Biomarkers of Aging Conference on October 20-21, 2025, at the Joseph B. Martin Conference Center at Harvard Medical School. Building on the momentum of our 2024 Conference and what we

A new paper "CMImpute: cross-species and tissue imputation of species-level DNA methylation samples across mammalian species" led by Emily Maciejewski building on our lab's mammalian methylation array collaboration with Prof Steve Horvath is now published genomebiology.biomedcentral.com/articles/10.11…

This is a VERY important study for my friends who believe in Rapamycin. While this is a very small pilot study with 10 patients and they only dosed 1mg for 8 weeks, no aging clocks, it tells many stories about the drug and its presence in the CSF. Read the paper.

Will comparative biology crack the epigenetic code to longevity? New imputed DNA methylation dataset covers 59 tissues from 348 mammals including long living species such as bowhead whale (211 years), bats, and the naked mole rat. Which tissue holds the key to longevity? Which

Among Hispanics, faster epigenetic aging (1st-generation clocks) flags Alzheimer’s: it tracks diagnosis and eight plasma markers, including p-Tau217, with strongest links in APOE-ε4 non-carriers. Replicated in ROS/MAP brain methylation. Quote: “…evidence for the future clinical

Self-rated deafness is linked to faster biological aging on two second-generation epigenetic clocks (GrimAge2, DunedinPoAm) even after adjusting for age, demographics, lifestyle and overall health. DNAm CRP, the GrimAge methylation proxy for C-reactive protein, mirrors this

Sincere apologies to everybody for my long silence concerning the "RMR1" study that we at LEV Foundation designed, and Ichor Life Sciences conducted, starting in early 2023. As of the last update I posted, only a few of the original 1000 mice remained alive, so there was really

Like an oil change for your blood: therapeutic plasma exchange (TPE) replaces old plasma with healthy fluid. Epigenetic clock analysis of a randomized controlled trial (N=42, adults 50+) found biweekly TPE with intravenous immunoglobulin (IVIG) most effective. Surprisingly, by

Genuine epigenetic rejuvenation in primary cells has long been the holy grail. A groundbreaking preprint reveals that over-expression of a single (secret) gene overcomes this barrier: greatly reduced age estimates across in fibroblasts and keratinocytes according to validated

Prof Steve Horvath Thanks Steve and built on the shoulders of the methylation clocks, your manuscript in T-shirt form for our celebration today!

“ER-100 [an epigenetic age reversal drug candidate] has demonstrated safety & efficacy in multiple pre-clinical animal models of disease” and is now heading into human clinical trials 👏 genengnews.com/topics/transla…

Gorgeous paper scientifically and artistically. Congrats to the team which included the Beijing Institute of Genomics, the Beijing Municipal Geriatric Medical Research Center, Juan Carlos Belmonte & Prof Steve Horvath 👏👏 cell.com/action/showPdf…