Lab goes out for a Dodgers game ⚾️

We stand by Jordan Chiles always!

FDA approves IDH1 and IDH2 inhibitor for brain cancer nature.com/articles/d4157… this is indeed a milestone that many of us have assisted almost in real time from that original science paper in 2008 (Parsons et al). Remarkable!

"News and views" from nature describing our groundbreaking study out today in Nature 🎉 So proud of Dr. Akriti Prashar and the Jones lab team and our collaborators! The Hospital for Sick Children (SickKids) Inner membrane turns inside out to exit mitochondrial organelles nature.com/articles/d4158…

I’ve been presenting our human stem cell embryo model, derived from programmed human ESCs, at conferences for a few years and last year, we finally published it. Now we’re excited to share a detailed protocol how to create these models #StemCellResearch nature.com/articles/s4159…

Congrats Kate Korobkina et al for our Nature Metabolism paper online now showing that in brown fat—a thermogenic tissue famous for generating vast amounts of acetyl-CoA in mitochondria—cytosolic acetyl-CoA synthesis also matters…ALOT. Find out why here: rdcu.be/dWUqM

Our latest out today nature! We revisit a century-old theory and show that metabolic gradients work hand-in-hand with genetic&signalling instructions to shape the embryo. Glucose isn't just an energy source, it acts as a major conductor of the body plan🍬 nature.com/articles/s4158…

Congrats to Berney Peng for being awarded an American Cancer Society Society Postdoctoral Fellowship to study mitochondria transfer in tumor heterogeneity and acquired resistance to therapy 🎉🥳🥳🥳🥳

"Cellular ATP demand creates metabolically distinct subpopulations of mitochondria" nature.com/articles/s4158…

Guess what? Mitochondria are weirder than we thought

How do mitochondria, the cell’s energy-producing organelles, perform competing metabolic processes? Segregation into distinct populations — one that makes energy-storing ATP molecules and one that does not — could explain it nature.com/articles/d4158…

Santa Monica lab outing to watch our admin assistant Amy Brown Carver’s directed and written short film Wow! On the big screen ETHOS Film Awards at the Laemmle Monica Film Center 🎞️ Wow! Can also be found on YouTube 🎥: m.youtube.com/watch?v=30cpky…

Teitell Lab kids at Santa Monica Pier 🎡

I’m excited to share new work out of the lab in Nature Metabolism today on the impact of tumor-relevant glucose concentrations on the response to pyrimidine synthesis inhibitors. nature.com/articles/s4225…. PDF: rdcu.be/d1vkV

New lab paper out in Aging Cell. Congrats Amy Vandiver and team Vahan Martirosian, PhD Mary Doan Jon Wanagat’s lab David Geffen School of Medicine at UCLA onlinelibrary.wiley.com/doi/10.1111/ac… Increased mitochondrial mutation heteroplasmy induces aging phenotypes in pluripotent stem cells and their differentiated progeny

Congrats DOCTOR! Bowen Wang! For defending his PhD thesis on the development of a new way to grow and measure how tumor organoids respond to therapy using high speed live cell interferometry

I'm swimming 5 miles to support the American Cancer Society Society. This swim is dedicated to my grandmother and aunt, who both lost their lives to cancer, and to the researchers striving every day to bring us closer to a cure gofund.me/fc752d90

Experience a #DayInTheLife of UCLA Broad Stem Cell trainee Mary Doan, a UCLA PhD candidate working to uncover therapeutic targets to manipulate metabolism in both health and disease in the lab of Dr. Michael Teitell Teitell Lab. 🍵👩🏻‍🔬🏞️ Credit: Joseph Doan