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Pleased to announce the first trial to demonstrate benefit of systemic therapy in appendiceal cancer. Atezolizumab and Bevacizumab; significantly improved PFS compared to synthetic cohort. 🟢Median PFS 18.3 vs 4.4m. 🙇‍♂️Thanks to John Paul Shen and Kanwal Raghav 🩺 🖖🏻 for mentorship.

Our study on human γδ T cells in mucosal and lymphoid tissues revealed increased frequencies, distinct functions, subsets, and site-specific compartmentalization in children compared to adults. with Josh Gray . Thanks to collaborators Todd M. Brusko Thomas Connors Peter Sims Yosef Lab

🚀 Exciting news! Check out our latest non-parametric strategy to eliminate batch effects and integrate single-cell protein measurements across CITE-seq datasets! Dive into the ✨ADTnorm✨ method details here:  biorxiv.org/content/10.110… #CITEseq #Bioinformatics #Singlecell

Well done Ye Zheng! This is a significant advancement for an often under-studied data type. Great to see a method specifically designed for CITE-seq data. Thanks to CZI Science and HIPC for their support. #CITEseq #DataScience #immunology

A few decades later, training is finally complete. A great feeling to celebrate the end of fellowship with such an amazing group of future oncologists. Honored to receive the Waun Ki Hong Award for Achievement in Basic Science Research. Thanks to all my mentors, friends and

Congrats on preprint study from some of our collaborators. Shows strategy to cut batch effects + integrate single-cell protein measures across CITE-seq datasets. Authors include Ye Zheng Raphael Gottardo 📊🧪🖥️ Peter Sims bioRxiv #FOCIS24 biorxiv.org/content/10.110…

Fantastic work and great to see additional strong evidence of predominant 5-ALA metabolism by myeloid cells in GBM.

ICYMI: check out our lab's latest publication in Cell, where we discovered that FGFBP1 is a novel marker of stemness in the intestinal epithelium cell.com/cell/abstract/…

Our collaborators Peter Sims Raphael Gottardo 📊🧪🖥️ + Ken Stuart create a "normalization" method for antibody-derived tags and integration across data sets. (Preprint) Research Square researchsquare.com/article/rs-457…

A cell state-specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma Peter Sims Peter Canoll Columbia University et al find quiescent astrocyte-like glioma cells show abnormal energy metabolism, sensitizing them to ferroptosis-inducing drugs embopress.org/doi/full/10.10…

Awesome collaboration with Anil K. Rustgi and colleagues!

Very happy to see my main project from residency Columbia Neurosurgery finally out! Cool story on mitochondrial #metabolic vulnerabilities and #ferroptosis linked to #GBM cell states. So grateful for the support from Jeffrey Bruce Peter Canoll Peter Sims Brent Stockwell Jan Kitajewski and others

And so it begins. This is required reading for all brain tumor docs. Vorasidenib: a new hope or a false promise for patients with low-grade glioma? | Nature Reviews Clinical Oncology nature.com/articles/s4157…

Thank you to everyone who attended the Annual DSB Retreat. We hope that you had a wonderful, science-filled time. Congratulations to the Best Poster Winners.

Congratulations to Drs. Sara Zaccara and Dian Yang. Well deserved!

Single-cell RNA sequencing to profile 215,680 *living* human #microglia across neurological diseases and CNS regions identifies disease-enriched subsets and tool compounds recapitulating microglial states John Tuddenham @HaageVc Mariko taga nature.com/articles/s4159…

🧵1/9 Excited to share our latest research on human microglia! We explored microglial heterogeneity through single-cell RNA sequencing of 215,680 live human microglia from 74 donors across neurological diseases. #NeuroImmunology #Microglia Nature Neuroscience nature.com/articles/s4159…

Another awesome collaboration with Donna Farber! Among many other experiments, we profiled antigen-responsive T cells across the body for COVID vaccine and flu with CITE-seq. Will be interesting to see if these findings generalize to other viruses and vaccines!

In a new study, Columbia Vagelos College of Physicians & Surgeons researchers discovered that mRNA COVID-19 vaccines prompt the immune system to store memory T and B cells—key for long-term immunity—in tissues like the lungs, spleen, and bone marrow. columbiamed.link/4eO8rI6