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Can metabolic processes instruct cell fate decision making during embryonic development? In our new preprint, we show an important role of glycolytic activity for the development of endoderm and mesoderm through the regulation of Nodal and Wnt signalling. biorxiv.org/content/10.110…

What a PERFFect day to share our new preprint! With Tsion Abay #BobStickels Meril Takizawa @ChaligneRonan and Ansu Satpathy, we introduce PERFF-seq, a new experimental approach to studying rare cells with scRNA-seq via transcript-specific enrichment. biorxiv.org/content/10.110… 1/n

Now Online: Origin, fate and function of extraembryonic tissues during mammalian development go.nature.com/3OELOeK

On reflection, I think this paper actually burys the lede about association studies. A more pointed conclusion might be that many tens or hundreds of millions of dollars in functional follow-up on disease-variant associations [1] have been essentially wasted, and are continuing

an important point on current-generation virtual cell models - pretraining on single cell atlases doesn't actually learn that many cell states

Biologists, stop putting UMAP plots in your papers! UMAP is a powerful tool for exploratory data analysis, but without a clear understanding of how it works, it can easily lead to confusion and misinterpretation. Link to Simply Statistics blogpost below.

Excited to share this collaborative work with @Hadhjantonakis and dana_peer led by Vidur Garg reporting drastically different interconversion efficiencies between ESC and XEN, unique trajectories mimicking in vivo states, and key plasticity barriers. cell.com/developmental-…

Researchers challenged longhorn crazy ants and humans with the same task: maneuvering a T-shaped object through two consecutive open doorways. Single humans always outperformed single ants, but ant groups could beat human groups. In PNAS: ow.ly/5vat50UwZAo

Cool! LUCA probably had CRISPR quantamagazine.org/all-life-on-ea…

Scientific drawing is an important skill that used to be an integral part of a scientists training 📝 I use vectors for my drawings- here are 5 reasons why they are awesome (1/6 🧵)

In my 40 years of biotech, I was waiting to see this result. Never before have transplanted cells survived normal immune response without immunosuppression. Excited for patients, many whom I know see hope today for a possible cure for many diseases. globenewswire.com/news-release/2…

Thanks for all the fish! Eddie Rashan

The sheer state of development of Egypt and Sumeria are strong circumstantial evidence that the history of civilization is far longer than previously believed. What we think of as the dawn of civilization is likely actually the peak of a forgotten #longhistory.

Progress in biology is too slow. Even simple experiments often take several days of work to complete. Software, by contrast, compiles in seconds. It's what makes programming "flow-inducing." We need faster feedback loops in biology. Our latest article explains where to start🔻

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by U.S. FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,

My new post is out 🧬 If you're not paying attention to the DNA sequencing landscape, you should be. Illumina's 80%+ market share is finally facing some highly innovative challengers. The next frontier emerges: from how do we read DNA to how will we interpret all of this new data

Cells are dynamic, messy and context dependent. Scaling models across diverse states needs flexibility to capture heterogeneity Introducing State, a transformer that predicts perturbation effects by training over sets of cells Team effort led by the unstoppable Abhinav Adduri

So you want to change transgene expression: just change your promoter, right? Changing the promoter increases RNA and thus protein levels. What more could be happening? [1/n] Well, promoters don’t just set RNA levels; they uniquely transform how RNAs are transmitted into protein

reprogramming cells with transcription factors is our most expressive tool for engineering cell state traditionally, we found TFs by ~guesswork ICML Conference we're sharing NewLimit's SOTA AI models that can design reprogramming payloads by building on molecular foundation models

As you know I'm obsessed with power laws in biology, which is a biological consequence of fundamental principles, like energy conservation from the first law of thermodynamics. Geoffrey West showed how highly optimized biological networks—think blood vessels or respiratory