Great story by White lab member Eduardo Cararo Lopes Rutgers Cancer Institute Ludwig Cancer Princeton University showing that mitochondrial respiration enables serine synthesis for the growth of lung cancer! Defective mitos cause dependence on dietary serine for tumor growth! rdcu.be/eAUIx

We mapped the zinc‑finger (ZF) “degrome.” High‑throughput ZF reporters + glutarimide analogs → new CRBN‑recruited degrons and design rules for degraders.

I'm thrilled to share our work from Jonathan Weissman's Lab (sciencedirect.com/science/articl…). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two mechanistically distinct strategies for mitochondrially localized translation.

🫵🏼 Join our awesome Dept (UMPhysiology)! This faculty search has a GI lean, backed by a super strong departmental emphasis/support… and a great team of pancreatic cancer researchers (Rogel and Blondy Center for Pancreatic Cancer, U-M Rogel Cancer Center). Please consider applying and share widely 🔁

We built upon a key discovery made by Kivanc Birsoy and unveiled additional mechanisms for regulating lipid synthesis. CHP1 promotes lipid droplet growth and regulates the localization of key enzymes for triacylglycerol synthesis | PNAS pnas.org/doi/10.1073/pn…

Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis biorxiv.org/content/10.110… #biorxiv_cellbio

In patients with localized colorectal cancer and PIK3CA hotspot mutations in exon 9 or 20, daily low-dose aspirin resulted in a significantly lower recurrence rate than placebo. Full ALASCCA phase 3 trial results and Research Summary: nej.md/4mpKXNp