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I've been working on variants of this problem for my entire career, and have only dreamed of designing molecules on the computer with success rates this high. Proud of Chai Discovery for pulling this off, and doing it with the speed, rigor and grace that was only imaginable ✨

Want to learn more? -> Check out Chai's report chaidiscovery.com/news/introduci… Want to validate your own models and test your proteins in the lab? -> Just go to our website and set up your first experiment adaptyvbio.com

I'm super excited by the Chai-2 announcement from Chai Discovery . The external validation by Adaptyv Bio is compelling. If all of the features shown below can become widely available, it will be a real coup for the "drug discovery underdogs" that I blogged about last week.

this is so good it's a bit hard to believe.

Congrats to the Chai team!

I'm super excited to be able to finally share this breakthrough with everyone!! It's been a true honor to be able to work on this project with my incredible teammates, and I can't wait to watch how Chai-2 transforms this space! You better believe we're only getting started 😎😎

We asked Joshua Meier (Co-Founder Chai Discovery) about the future of AI in biotechnology. "We have scientists working for years trying to enable a certain class of drug program." "If we can use machine learning to jump to potential (drug) solutions, that could really push up the

It takes true inventiveness to break ground. This is pioneering work! And it makes me so happy to see Josh’s life’s work coming to life. Congratulations Joshua Meier, Jack Dent, Matt McPartlon, Kevin Wu, Nathanael Rollins, Jacques Boitreaud, danny, Zhuoran Qiao / 乔卓然, Paul Wollenhaupt & Alex!

Biotech will never be the same again. Congrats Josh and Chai Discovery.

This startup just dropped an AI model that will save many many lives. Chai-2 takes stubborn proteins and gives you a verified binder in 2wks, instead of 6-18mos. Its 16% hit rate is 100x better than previous methods! Medicine development is about to get way cheaper and faster.

Some use cases are cooler than others, and it's safe to say zero-shot antibody design is one of them. Congrats on launching Chai-2!🧬

Chai Discovery Do we see a TopK SAE at 0:19 👀 In all seriousness - incredibly cool work!

🆕!! AI and atomic-level structure prediction are accelerating drug discovery — turning a slow, empirical search process into something closer to molecular engineering. Joshua Meier Jack Dent co-founders Chai Discovery chat their new bio foundation model, Chai-2. It enables

Listen to today's No Priors to hear why the Chai Discovery team is bullish on biotech. Thank you to sarah guo // conviction for hosting Jack Dent and Joshua Meier.

Chai Discovery dropped Chai-2, an AI that can design working antibodies It designed antibodies against 52 diseases and found successful treatments for half of them by testing 20 candidates each The process normally takes months or years

Zero-shot antibody design in a 24-well plate Chai Discovery 1. Researchers have introduced Chai-2, a multimodal generative model that marks a significant leap in de novo antibody and miniprotein design. This platform achieves an impressive 16% hit rate in de novo antibody

Chai-2 is now up on BioRxiv: biorxiv.org/content/10.110…

Congratulations to the winners of the 2024 Chen Institute and Science Magazine AI Prize! Winners share $50,000 in cash awards and their research essays will be published in Science. Learn more about grand prize winner Zhuoran Qiao / 乔卓然 and finalists Dr. Alizée Roobaert 🐠 and Aditya Nair ~ ആദി here:

🎉 Congratulations to Zhuoran Qiao / 乔卓然 for winning the Chen Institute and Science Magazine AI Prize, recognizing his groundbreaking AI research in biochemistry. We’re honored to have him on the Chai Discovery team!

Anthropic's recent blog post provides a good summary of some of the recent work applying mechanistic interpretability to biology. I am very bullish on this research direction!