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Our newest Cats have the #synbio community SHOOK! We’re thrilled to welcome Flora Zhiqi Wang, Rachel F Weissman, and Jorge Rodriguez to the lab!

Excited to join the Savage lab!🥼🧪🧬

New this week! In vivo continuous evolution takes advantage of cycles of rapid mutation, amplification and selection inside living cells @cnb_csic CSIC Beatriz Alvarez Luis Ángel Fernández Chang Liu Haiqi Chen UTSW Science Frances Arnold Rosana go.nature.com/3FXKnCK

Check out our paper and the accompanying perspective by Kuhlman published today in Science Magazine about the surprising role of short tandem repeats in regulating eukaryotic transcription! science.org/doi/10.1126/sc… science.org/doi/10.1126/sc… A thread (1/11):

The human genome contains about 20,000 protein-coding genes. A recent study proposes that they may be regulated by loose “committees” of molecules collected by unusual segments of DNA. @philipcball reports: quantamagazine.org/a-lobby-where-…

What limits rubisco function? Is it the chemical mechanism? Evolution? In an updated pre-print Michael Prywes et. al explore this question by assaying >99% of single amino acid mutants in Form II rubisco (1/7)

read the whole thing here! biorxiv.org/content/10.110…

What's better than 1 deep mutational scanning (DMS) library? 2! In a new pre-print Brittney Thornton and Rachel F Weissman et al. map the mutational landscape of ISDra2 TnpB protein and reRNA and leverage these datasets to engineer highly active variants (1/9)

Congrats to team TnpB Rachel F Weissman and Brittney Thornton for getting this story out! Not just one, but two DMS scans covering both protein and RNA, with plenty of insights on the sequence-function landscape and some important engineering successes!

This week, I’ll highlight two significant recent CRISPR advances: 1) BEAM’s exciting Phase 1 clinical data for BEAM-302. 2) Impressive work from the labs of Scribe’s co-founders Dave Savage & Jennifer Doudna—providing a textbook example on engineering CRISPR enzymes from zero to

Why I like it: beyond showcasing TnpB as an exciting new small CRISPR enzyme, this study provides a clear playbook for modern molecular engineering. Comparing this work with others in the field, it is clear that comprehensive mapping of protein & RNA variants can surpass the

We love generating data! But what should we do with it? We collaborated with the Jennifer Listgarten on ProteinGuide - a new method for using experimental data to guide protein generative models. Congrats to Junhao (Bear) Xiong, Hunter, Maria Lukarska, Ishan Gaur and Luke Oltrogge! ⬇️⬇️