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A synthetic cell-free 36-enzyme reaction system for vitamin B12 production nature.com/articles/s4146…

With CRISPR-Cas9, a repressor of fetal hemoglobin expression was disrupted in hematopoietic stem cells from three persons with sickle cell disease. Edited cells were reinfused. Hematopoiesis was restored. Read the full study results: nej.md/3L64brp

Today we report in Cell a suite of engineered and PACE-evolved prime editor variants PE6a-g. These new prime editors improve the activity, in vivo deliverability, and in vivo editing efficiency of prime editing. sciencedirect.com/science/articl… PDF:drive.google.com/file/d/11959ct… (1/15)

Today we report in Nature Chemical Biology a collaboration led by Haoxin Li in Ben Cravatt's lab to illuminate functional and druggable cysteines in the human proteome by integrated base editing and activity-based protein profiling. nature.com/articles/s4158… PDF: drive.google.com/file/d/1hky1Ye…

Delighted to share publication in PPB Journal. Amol Jadhav 김재연 Jae-Yean Kim Unlocking secrets of nature's chemists: Potential of CRISPR/Cas-based tools in plant metabolic engineering ... sciencedirect.com/science/articl…

Fortunate to deliver an invited talk in XVI ASC 2023 at Kochin, Kerala from 10-13 Oct 2023. Interacted with eminent scientists and met with friends 😊. Sincere thanks to NAAS and ICAR-CMFRI for the invitation and excellent arrangements and hospitality.....

Delighted to share a paper published in the BMB Reports Journal published by the KSBMB Society. 김재연 Jae-Yean Kim Dibyajyoti Pramanik, PhD “CRISPR base editor-based targeted random mutagenesis (BE-TRM) toolbox for directed evolution” bmbreports.org/journal/view.h…

Delighted to share a paper published in The Nucleus Journal. rdcu.be/dAk8Y “#Cas9 variants expand the targeting scope of base editing systems in bacteria” doi.org/10.1007/s13237…

Alyssa is the first patient to receive a base edited therapeutic (triply base edited CAR-T cells that cleared her T-cell leukemia), doing well now more than two years post-treatment thanks to the efforts of Waseem Qasim’s team and GOSH.

Workshop-cum-Webinar on #CRISPR-based #genome_ediitng.

Delighted to share a paper published in Plant Reproduction. “Application of genome editing in plant reproductive biology: recent advances and challenges” doi.org/10.1007/s00497…

Excited to discuss prokaryotic vs. eukaryotic genome editing at #GEW24 with @RahulShelake, Research Professor at Gyeongsang National University, Jinju, Korea. #CRISPR #Biotechnology #GeneEditing

Review by Rahul M Shelake et al. Sopan Wagh 김재연 Jae-Yean Kim Plants MDPI MDPI #Heat Stress and Plant–#Biotic Interactions: Advances and Perspectives mdpi.com/2223-7747/13/1… #PlantSci Agronomy MDPI Biotic stress in Plants 🍀☘️🌴☘️🌿🌹🌺🕷🪰🐜🐞🐝🐛 Tangwa Abilu.🌿🌏🌾🍀🍃.SDG's. 🇺🇳 #UN 🇺🇳 #SDGs 🌏 #ClimateAction 🌐 #ActNow Plant Science Carbon Credit Coin Blockchain Token Information Marine heatwaves

Review by Rahul M Shelake et al. Sopan Wagh 김재연 Jae-Yean Kim Plants MDPI #Heat Stress and Plant–#Biotic Interactions: Advances and Perspectives mdpi.com/2223-7747/13/1… #PlantSci Biotic stress in Plants 🍀☘️🌴☘️🌿🌹🌺🕷🪰🐜🐞🐝🐛 🇺🇳 #UN 🇺🇳 #SDGs 🌏 #ClimateAction 🌐 #ActNow SAVE the Earth @ #ClimateChange The Crop Trust 菊地護 hot science ScienceAlert CropX New Zealand (Regen) Ltd Imtrade CropScience Top Science

Review by Rahul M Shelake et al. Sopan Wagh 김재연 Jae-Yean Kim Plants MDPI #Heat Stress & Plant–#Biotic Interactions: Advances & Perspectives mdpi.com/2223-7747/13/1… #PlantSci hot science ScienceAlert Top Science Tosari Crop Research Centre Peter M @SocietyCrop Group for High Resolution Sea Surface Temperature Plant Science Biotic stress in Plants 🍀☘️🌴☘️🌿🌹🌺🕷🪰🐜🐞🐝🐛 🇺🇳 #UN 🇺🇳 #SDGs 🌏 #ClimateAction 🌐 #ActNow

Review by Rahul M Shelake et al. Sopan Wagh 김재연 Jae-Yean Kim Plants MDPI MDPI #Heat Stress and Plant–#Biotic Interactions: Advances and Perspectives mdpi.com/2223-7747/13/1… #PlantSci 🇺🇳 #UN 🇺🇳 #SDGs 🌏 #ClimateAction 🌐 #ActNow Plant Science Cold Spring Harbor Laboratory Indian Council of Agricultural Research. Indian Botanists Feed the Future Cory Willness Plantlife

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

A CRISPR-based tool HACE was developed for long-range, targeted mutagenesis of >1000 base pairs in mammalian genomes, allowing the exploration of genetic variants' effects on gene function and regulation in both coding and non-coding regions. science.org/doi/10.1126/sc… #NBThighlight