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It’s time to change this slide! FDA approval today of #sotorasib. Congrats @JonathanOstrem & Ulf Peters on launching the successful attack with tethering from Jim Wells and scientists at Wellspring! Many steps-great to see the summit reached!! UCSF Helen Diller Family Comprehensive Cancer Ctr HHMI

Our new collaborative paper with Dr. Keila Torres, sheds light into the biology of and suggests therapeutic approaches for PRC2-deleted MPNST - a soft-tissue sarcoma. link.springer.com/article/10.100… Led by Veena Kochat & Ayush Raman . MD Anderson Cancer Center .

Also, sharing a review we wrote about application of machine learning tools in epigenomics with a focus on cancer research. Emre Arslan Jonathan Schulz sciencedirect.com/science/articl…

Our study on chromatin states in metastatic melanoma came out today. We demonstrate genotype-specific chromatin state patterns and suggest use of PRC2 inhibitors in NRAS-mutant melanoma. cell.com/cell-reports/f… Ming "Tommy" Tang Chris Terranova Mahinur Maitituoheti MD Anderson Cancer Center

We are looking for two motivated and talented 'Senior Research Scientists" with expertise in protein biochemistry and CRISPR/Cas screening at MDACC Epigenomics Initiative (METI). Biochemist position: bit.ly/3lAPFMc Biology Position: bit.ly/2YK7Nda

Congrats to @HusseinAbbas01, my postdoc Dapeng and the team | Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy ⁦Naval Daver, M.D.⁩ ⁦Kunal Rai⁩ MD Anderson Cancer Center⁩ nature.com/articles/s4146…

Collaborative work with @HusseinAbbas01 Naval Daver, M.D. Linghua Wang, MD, PhD online now. Katarzyna (Kasia) Tomczak Praveen Barrodia from my lab contributed significantly to this work. Congrats to all! nature.com/articles/s4146…

New research identifies mechanisms behind how fasting can reduce the negative effects of high-dose chemotherapy and radiation therapy: fal.cn/3kqFD Kunal Rai Cullen Taniguchi, MD #EndCancer

Chris Terranova, Kristina Stemler, Kunal Rai, Helen Piwnica Worms and collaborators - Reprogramming of H3K9bhb at regulatory elements is a key feature of fasting in the small intestine cell.com/cell-reports/f…

BREAKING NEWS: CPRIT announces 74 new grants for over $112 million to expand innovations in cancer research and prevention in Texas. Check out the release for the entire list of awards. #CPRIT #TexansConquerCancer ow.ly/1AQ050HWOem

Thankful to CPRIT for their support of our research. MD Anderson Cancer Center

Our collaborative work with Joe Ludwig on DSRCT,showing AR as a therapeutic target that functions through epigenome reprogramming, appeared today in Nature Communications . Mahinur Mattohti MD Anderson Cancer Center nature.com/articles/s4146…

Comparable tumor immune microenvironment in human glioblastoma & murine model: buff.ly/3OdgOk3 Zamler_Brain @Jianhu_Neural @draettag Amy Heimberger, MD Lurie Cancer Center Malnati Brain Tumor Institute at Northwestern MD Anderson Cancer Center Stephanie Watowich Kunal Rai @tcellsrus Laura Kahn @cinziakas Kristin Huntoon Katarzyna (Kasia) Tomczak

Preprint Kunal Rai MD Anderson Cancer Center with Genevieve Boland, MD, PhD Mass General Cancer Center Manolis Kellis Massachusetts Institute of Technology (MIT): Enhancer Reprogramming in Melanoma Immune Checkpoint Therapy Resistance biorxiv.org/content/10.110… Nice data from high throughput profiling of clinical samples to functional perturbation study.

Our preprint on epigenome reprogramming in R and NR melanoma patients treated with ICB suggests an enhancer biomarker and BETi+aPD1 combo. Great collaboration with Manolis Kellis Genevieve Boland, MD, PhD Mahinur Mattohti Ming "Tommy" Tang Jennifer Wargo MD David Liu MD Anderson Cancer Center biorxiv.org/content/10.110…

Happy to share our Review on chromatin state dynamics and computational tools to explore differential CS in normal vs. cancer cell | @ Briefings in Bioinformatics | w/ Ayush Raman | academic.oup.com/bib/advance-ar… | Princess Margaret Cancer Centre Research Broad Institute MD Anderson Cancer Center #epigenomics #chromatin

Recently got my trophy for Potu N Rao Award for Excellence in Basic Science 2022. Many thanks to Division of Cancer medicine MD Anderson Cancer Center for the recognition. I owe to this to the tireless efforts of the present and past trainees in my lab.

Our new study shows NRF2-driven enhancer reprogramming contributes to chemotherapy resistance in head and neck cancers, providing rationale for targeting NRF2 to overcome cisplatin resistance. Led by Emre Arslan and Dr. Abdullah Osman. MD Anderson Cancer Center aacrjournals.org/clincancerres/…

Honored and thrilled to receive Young Alumni Achiever Award 2023 from my alma mater, Indian Institute of Technology, Kharagpur IIT Kharagpur🇮🇳

Join us at #FoGBoston for insights from Kunal Rai (Associate Professor & Scientific Director, MD Anderson Cancer Center Epigenomics Therapy Initiative) on his work surrounding the role of #epigenetic changes in cancer progression. More info here: hubs.la/Q022tvn70 #cancergenomics