Debate surrounds the function of the most abundant modified nucleotide in mRNA, m6A, and m6A-binding proteins, YTHDF1, 2, and 3. This Perspective examines different data and how emerging data is changing our understanding of #YTHDF proteins and of #m6A bit.ly/3UvuVqr

GoT-ChA! I am thrilled to announce that our paper "Mapping Genotypes to Chromatin Accessibility Profiles in Single Cells" is now out in nature !! 👩‍🔬👨‍🔬🧬If you want to link somatic mutations to epigenetic changes directly in patient samples: nature.com/articles/s4158… 👇🧵

Awesome masterpiece from Dan Landau! Kudos to @sars_ganesan and the entire team for their dedication and brilliance! 🌟🔬

🍭new pre-print! In collab. with Mission Bio , we developed single-cell Genotype-to-Phenotype (scG2P) for targeted co-capture of DNA & mRNA! We explore esophagus clonal mosaicism, defining clonal structure the phenotypic impact of somatic drivers biorxiv.org/content/10.110…

🚨 Paper Alert! 🚨 Does RNA regulation impact the p53 pathway and DNA damage response? We reveal distinct m6A-dependent and independent functions of the YTHDC1 protein. Proud of the work by Daniel Elvira Blázquez Cima Universidad de Navarra, collaboration with Raimondi Ivan NY Genome Center 🔗 Read here 👇

Don’t procrastinate and sign up to attend the 2nd @NYCRNASymposium! Abstract deadline is in less than two weeks away!! A free day of opportunities to present and network. Can’t wait to see you on September 24!

Interested in single-cell epigenomics? Check out my latest review focusing on experimental methods for multifactorial chromatin profiling: portlandpress.com/biochemsoctran…

Some exciting news to share! Our lab is relocating to Harvard Medical School Systems Biology and Brigham and Women's Hospital GI & Genetics this fall. We're actively recruiting talented postdocs to join our team. Please RT to spread the word.

We are looking to grow our team at Neptune Bio in NYC. Come and join us developing next generation therapies! linkedin.com/jobs/view/4115…

Interested in single cell genomics but need help getting started? Check out my lab's Single Cell Genomics Day on April 25. Talks will feature recent exciting computational and experimental advances and will be live-streamed at satijalab.org/scgd. Please RT/spread the word!

What happens when sequencing costs go ⏬ ? Imagination and new opportunities go ⏫ Dan Landau Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the Ultima Genomics platform 🧵👇 Lets goooo!! rdcu.be/ehkUb

Excited to share our exploration Nature Methods into new horizons opening up in the era of low cost sequencing! 🔥 Deeper sequencing at WGS scale for PPM sensitivity of tumor informed MRD 🔥Duplex sequencing at WGS scale for plasma only exploration of ctDNA Check out thread 👇

we're recruiting for a scientist to join our Talent team NewLimit this is a unique chance for a scientist to move into the business & ops side of biotech. we imagine recent PhDs & postdocs looking to transition away from the bench are great candidates. you'll be working very