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Happy to share our new paper on functional dissection of dense enhancer cluster at 9p21 locus. Congrats Umer Farooq. An interdependent network of functional enhancers regulates transcription and EZH2 loading at the INK4a/ARF locus: Cell Reports cell.com/cell-reports/f…

"Education isn't something you can finish." -- Isaac Asimov (1920 - 1992)

New preprint from the lab! Cis-regulatory effect of HPV integration in cervical tumours. Work lead by Anurag Kumar Singh in collaboration with Kaivalya Walavalkar Dimple Notani Daniele Tavernari @CirielloLab. Tweetorial👇biorxiv.org/content/10.110…

Our fascinating idea of how enhancers could reinforce their action on target promoters by transcribing neighbouring boundaries!

Transcription factor condensates and signaling driven transcription tandfonline.com/doi/full/10.10…

RNA binding limits the ligand induced transcriptional potential of estrogen receptor-alpha biorxiv.org/cgi/content/sh… #bioRxiv

Do participate in this meeting on the Interdisciplinary aspect of chromatin organization and gene regulation at ICTS Bangalore (ICTS) in September 2024. Pedagogical workshop + conference. Register here: icts.res.in/program/chroma… Dimple Notani mithunmittir

I am excited to share our preprint on mitotic H3S10p's role in maintaining the interphase chromatin state of a cell! Check it out… I am thankful to Dimple Notani National Centre for Biological Sciences ;all the authors Sachin Mishra ARIF HUSSAIN NAJAR Anurag Kumar Singh Rajat Mann and Notani Lab

What is the significance of transcription factor binding to regulatory RNA? Dimple Notani and colleagues National Centre for Biological Sciences show that it stabilizes ERα binding to promoters with weak recognition motifs, but also reduces their transcriptional output embopress.org/doi/full/10.10…

1/n: Super excited to present our work! Huge thanks to my PI, Dimple Notani and all my co-authors: Rajat Mann, Bharath S and Tripti Kharbanda and National Centre for Biological Sciences

Paper alert from the lab! We developed a new inducible dual-color reporter to study M6PR trafficking spearheaded by Mallika Bhat. Congratulations to all authors involved and JNCASR Bangalore Ravi Manjithaya

Paused Polymerase synergises with transcription factors and RNA to enhance the transcriptional potential of promoters biorxiv.org/cgi/content/sh… #biorxiv_molbio

We are excited to share our latest work: Transposable elements are deregulated in #Preeclampsia, which correlates with type-I IFN levels. "TE signature in maternal cell-free RNA can predict preeclampsia before the appearance of symptoms" biorxiv.org/content/10.110…

Excited to share that our review article, "Role of ATP-dependent chromatin remodelers during meiosis," has been published in Trends in Genetics (Cell Press). Read the full article here: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…

“Excited to share a preprint of part of my thesis work! 🧬 This study highlights fascinating structural insights into WT and Fmr1 KO hESC ribosomes. Thankful to all the co-authors. Feedback is most welcome! #ribosome #hESCs #StructuralBiology National Centre for Biological Sciences Tata Institute of Fundamental Research

#PhDone! 🎓 Congratulations Dr Rajat! 🎉 Rajat Mann from Dr Dimple Notani's lab successfully defended his thesis! 🧵⬇️Scroll through the thread to learn about his work on transcription regulation🧬 (1/5)