Ramon Grima (@ramon_grima) 's Twitter Profile
Ramon Grima

@ramon_grima

Professor of Computational Biology, University of Edinburgh.
Stochastic modelling of gene expression and intracellular biochemical dynamics.

ID: 1453602450787782660

linkhttps://grimagroup.bio.ed.ac.uk/ calendar_today28-10-2021 06:00:23

76 Tweet

330 Followers

255 Following

Davide Mazza (@shiner80) 's Twitter Profile Photo

Proud to share our latest preprint: we explore how chromatin organization and transcription factor search are related using a freshly built 🔬, to combine single molecule tracking of nuclear factors with structured illumination imaging of DNA. biorxiv.org/content/10.110…

bioRxiv Biophysics (@biorxiv_biophys) 's Twitter Profile Photo

Exact solution of a three-stage model of stochastic gene expression model including cell-cycle dynamics biorxiv.org/cgi/content/sh… #biorxiv_biophys

Lior Pachter (@lpachter) 's Twitter Profile Photo

#scRNAseq is a multimodal assay producing two count matrices: unspliced & spliced counts (e.g. for RNA velocity). Which should be used for clustering? Can they be used together? If so, how? Tara Chari w/ Gennady Gorin answer some of these questions in biorxiv.org/content/10.110… 1/🧵

Diego Oyarzún (@doyarzunrod) 's Twitter Profile Photo

Job alert📢 We are recruiting for 4 year postdoc fellowships. Up to 3 posts available. If you want to dive into quantitive biomedicine using cutting-edge models and data, this is the place for you. …oss-disciplinary-fellowships.ed.ac.uk ANC@Edinburgh Biological Sciences | University of Edinburgh Centre for Engineering Biology #ai #machinelearning #synbio

Duncan Sproul (@sproul_lab) 's Twitter Profile Photo

Help us understand how DNA methylation patterns are regulated at the single-molecule level using Oxford Nanopore sequencing. PhD available with myself and Ramon Grima MRC_HGU Institute of Genetics and Cancer Biological Sciences | University of Edinburgh, deadline 27th Nov. ed.ac.uk/mrc-human-gene… #epigenetics #Bioinformatics Please RT

Help us understand how DNA methylation patterns are regulated at the single-molecule level using <a href="/nanopore/">Oxford Nanopore</a> sequencing. PhD available with myself and <a href="/ramon_grima/">Ramon Grima</a> <a href="/mrc_hgu/">MRC_HGU</a> <a href="/EdinUni_IGC/">Institute of Genetics and Cancer</a> <a href="/SBSatEd/">Biological Sciences | University of Edinburgh</a>, deadline 27th Nov.
ed.ac.uk/mrc-human-gene…
#epigenetics #Bioinformatics
Please RT
NimwegenLab (@nimwegenlab) 's Twitter Profile Photo

How many distinct gene expression states are present in a given scRNA-seq dataset, and what are they? Maybe surprisingly, as Pascal Grobecker shows in his PhD work, there is a unique rigorous answer to this question, free from any tunable parameters. 1/n t.ly/hMPnV

Matthew Swaffer (@mpswaffer) 's Twitter Profile Photo

. . . and we’re now looking for motivated & talented postdocs to join us in 2024. We're a multidisciplinary group that combines approaches across cell, molecular, systems & quantitative biology. If that sounds up your street please get in touch - I’d love to hear from you! (9/9)

The Journal of Chemical Physics (@jchemphys) 's Twitter Profile Photo

This week's cover features work published in the 2023 Emerging Investigator collection! Impressive modeling of stochastic gene expression by Yiling Wang, Zhenhua Yu, Ramon Grima , & Zhixing Cao (Queen's Chem Eng) Read it here: pubs.aip.org/aip/jcp/articl…

This week's cover features work published in the 2023 Emerging Investigator collection! 
Impressive modeling of stochastic gene expression by Yiling Wang, Zhenhua Yu, <a href="/ramon_grima/">Ramon Grima</a> , &amp; Zhixing Cao (<a href="/QuCHEE/">Queen's Chem Eng</a>)

Read it here: pubs.aip.org/aip/jcp/articl…
Gennady Gorin (@goringennady) 's Twitter Profile Photo

I am thrilled to announce that my new article with Lior Pachter, "New and notable: Revisiting the 'two cultures' through extrinsic noise," is out in Biophysical Journal! cell.com/biophysj/fullt… 1/

Ramon Grima (@ramon_grima) 's Twitter Profile Photo

I am happy to share our latest preprint biorxiv.org/content/10.110… where we devise a simple but effective method to estimate the total number of regulatory steps in transcription initiation, splicing, and nuclear export from the increase in mean mRNA, a short time after induction

I am happy to share our latest preprint biorxiv.org/content/10.110… where we devise a simple but effective method to estimate the total number of regulatory steps in transcription initiation, splicing, and nuclear export from the increase in mean mRNA, a short time after induction
Ramon Grima (@ramon_grima) 's Twitter Profile Photo

How does the bursty character of gene expression vary across the cell-cycle? In recent work with Augustinas Šukys we answer this question by fitting mechanistic models of gene expression to scRNA-seq data in mammalian cells biorxiv.org/content/10.110…

How does the bursty character of gene expression vary across the cell-cycle? In recent work with <a href="/AugustinasSukys/">Augustinas Šukys</a>  we answer this question by fitting mechanistic models of gene expression to scRNA-seq data in mammalian cells biorxiv.org/content/10.110…
Lyndsay Kerr (@_lyndsay_94) 's Twitter Profile Photo

I’m excited to advertise a fully-funded PhD studentship! To find out how you could use maths and stats to understand DNA processes click here: strath.ac.uk/studywithus/po… MathsStats@Strath.

I’m excited to advertise a fully-funded PhD studentship! To find out how you could use maths and stats to understand DNA processes click here: strath.ac.uk/studywithus/po… <a href="/StrathMathStat/">MathsStats@Strath</a>.
Rubén Pérez-Carrasco (@2piruben) 's Twitter Profile Photo

Excited to share our new paper building a mathematical framework to study developmental tempo differences across species using orbital equivalence 🕐🐁↔️🕑🐒 Grateful to count with Charlotte Manser in the team! journals.biologists.com/dev/article/do…

Moffitt Laboratory (@moffittlab) 's Twitter Profile Photo

So excited to announce our new method for multiplexed RNA imaging in bacterial cells: bacterial-MERFISH! A huge congratulations to the team of Ari Sarfatis, Yuanyou Wang, and Nana Twumasi-Ankrah! Check out the following thread or our bioRxiv (biorxiv.org/content/10.110…) 1/12

Ramon Grima (@ramon_grima) 's Twitter Profile Photo

Excited to share our paper on Holimap nature.com/articles/s4146…, a new method that accurately and rapidly predicts the stochastic dynamics of complex gene regulatory networks by mapping them to much simpler systems #Genomics #Bioinformatics

Centre for Engineering Biology (@edengbio) 's Twitter Profile Photo

Glad to see this workshop running for a second year. It’s a great opportunity for early career researchers to build new collaborations, both locally and internationally. Register now and consider participation!

Ramon Grima (@ramon_grima) 's Twitter Profile Photo

I have an opening for a postdoctoral research associate in my group at The University of Edinburgh to develop new mathematical models of bursty gene expression and signal transduction and fit these to eukaryotic data. Deadline 24th March. jobs.ac.uk/job/DMA024/pos…