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Thank you ESPKU for the opportunity to present our results of the interventional part of the PICO study! The scientific programme was very exciting and we‘ve learned a lot from all the speakers! NSPKU

Some discussion about synthetic probiotics in PKU at the #ESPKU2023. 2 strains of the probiotic Escherichia coli Nissle 1917 have been shown to metabolise Phe in the gut.

Very proud of our PhD student Anna Wyss for winning the ✨Best Poster Prize in the Category „Best Multidisciplinary Research“✨ at the Day of Clinical Research in Bern🥳!! Well done!! Universität Bern Insel Gruppe Uni Fribourg

PKU in Adults: What do we know? An editorial by Robin Lachmann and Mirjam Langeveld. pubmed.ncbi.nlm.nih.gov/38296030/

Do you have PKU and want to take part in a research study? Contact the study coordinator, Scout Bolton, to learn more or to participate!

👏👏Huge congrats to simone poli on successfully defending his PhD on multiparametric and multinuclear MR methods for studying human glucose metabolism 🎉 Fantastic work! So very well deserved! 🥳🎓! Insel Gruppe Universität Bern

📣 New evidences on neurological impact of high Phe-levels in #PKU adults. A 4-week high phenylalanine exposure results in transient reductions of the cortical grey matter and worse cognitive performance.

Open position in my lab 📯 Postdoctoral researcher in Youth Mental Health (80-100%) at Faculty of Psychology University of Basel unibas.ch/de/Arbeiten-an…

In this new Reports article drawn from PICO data, Raphaela Muri and colleagues pose an often asked question: Do early-treated adults with phenylketonuria sense high phenylalanine levels? Laura Hauri, et al Answer here 👉🏻 doi.org/10.1002/jmd2.1… #PKU

It seems that adults with early-treated #phenylketonuria #PKU cannot effectively identify high Phe levels but I agree with the authors that an increase from 300 to 1000 μmol/L could be perceived differently than from 700 to 1400 μmol/L

🚨Check out the latest JIMD shortcast featuring my boss and Co-PI of the PICO-study, Dr. Roman Trepp, discussing our recent publication on whether adults with #phenylketonuria 🧬 can sense when their phenylalanine levels are high ⬇️ Insel Gruppe Universität Bern

🧠Just published at Brain this awesome randomized trial from Raphaela Muri et al. showing that 4 weeks of high phenylalanine exposure in early-treated adults with phenylketonuria #PKU results in REVERSIBLE reductions of cortical grey matter! academic.oup.com/brain/article/…

Muri et al have previously demonstrated white matter changes in adults with early treated PKU. In new work they show that temporary exposure to high Phe levels leads to reversible white matter changes. doi.org/10.1002/jimd.1… Raphaela Muri #pku