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Deep learning researchers have been predicting that it will make various jobs obsolete, that self-driving cars are imminent, and they're on a path to AGI. Many of them really believe the hype. To resist it, we must understand the culture that produces it. aisnakeoil.substack.com/p/why-are-deep…

more fallout from the reproducabiliy crisis, potentially affecting tens of thousands of studies: Principal Component Analyses (PCA)-based findings in population genetic studies are highly biased and must be reevaluated nature.com/articles/s4159…

I think we need to talk about how devastating this cancer microbiome refutation paper from Steven Salzberg 💙💛 and colleagues is. It really speaks to how devoid of critical thinking and intellectual depth our glam publishing ecosystem has become. 1/n biorxiv.org/content/10.110…

Ready to nerd out on random forests? Someone wrote an entire Ph.D. thesis on random forests ❤️ 200 pages of gems. Highlights: Why ensembles work, interpretability of forests, and making random forests work on huge datasets. buff.ly/3QbTC9o

🧵 Understanding Heteroscedasticity: A Medical Guide 1/ 🤔 What's Heteroscedasticity? Imagine you're trying to predict a patient's blood pressure based on their age. If the spread of blood pressure readings varies widely at different ages, that's heteroscedasticity. In simple

Delighted to share the success of the Science Outreach and Career Shaping event held at University of Kashmir, through the collaboration of the 4th IndiaBioscience Outreach Grant (IOG) awardees. Appreciations to Peer Abdul Haseeb Syed, Mübarak Hussain Saima Beigh Dr Ajaz, Mir Zahoor Gul for their efforts.

Revolutionizing 3D Genome Analysis: AI Unveils the Optimal Resolution for Hi-C Data Integration – A New AI-Powered Method for Automatically Determining the Best Bin Size – communities.springernature.com/posts/revoluti… I have introduced my most recent publication in Behind the paper!

DeTikZify is out on Hugging Face Synthesizing Graphics Programs for Scientific Figures and Sketches with TikZ

New controlled study of AI voice mode on mental health finds complex results GPT-4 with an empathetic voice reduced loneliness, but heavier users, and especially when use was combined with a more neutral voice or those with particular personalities, had multiple negative impacts

PISA: a versatile interpretation tool for visualizing cis-regulatory rules in genomic data biorxiv.org/content/10.110…

Regulatory sequence ML has been widely applied to predict substitution SNP effects (to promising results!), but most teams have shied away from indels. biorxiv.org/content/10.110…

1/17 Confused by plus/minus strands, coding/template, or forward/reverse in DNA data? You're not alone. Here's how to never mix them up 🧵

A curated knowledge bank every developer wishes they had sooner.

It isn’t crazy to think that o3 is AGI, but this says more about AGI than o3 Many prominent AI commentators have called o3 a kind of AGI: Tyler Cowen says that if you know AGI when you see it, then he has seen it. Ethan Mollick describes o3 as a jagged AGI. What is it about o3

BREAKING: Apple just proved AI "reasoning" models like Claude, DeepSeek-R1, and o3-mini don't actually reason at all. They just memorize patterns really well. Here's what Apple discovered: (hint: we're not as close to AGI as the hype suggests)

How is it even news that LLMs won't get us to AGI, reasoning or not. I thought we'd settled this last year.

One thing that really bothers me with the new "virtual cell" terminology is that is currently largely focused on a very narrow definition of models that can predict effects of trans perturbations (gene dosage, drugs etc) on gene expression. 1/

It is insane how underrated these blogs are Man made an interative visualization for different kinds of attention mech (He has interactive visualizations for RNNs, LSTMs, CNNs, and so much more)

We’re excited to share a follow-up Borzoi training run and an analysis of the capabilities that emerged. biorxiv.org/content/10.110…

We’ve done some experiments, but the metrics aren’t conclusive, so choose your own adventure! We’ve released these models open source, open weight for all to use. github.com/calico/borzoi-…