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🚀 Proud to launch ⭐Path2Space⭐ — the first AI to discover spatial biomarkers for cancer treatment! It predicts spatial gene expression from histopathology, enabling large-scale tumor microenvironment profiling. biorxiv.org/content/10.110… 🧵1/11

In collaboration with Reuben Saunders, Jonathan Weissman's Lab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue. Check it out! biorxiv.org/content/10.110…

The 2024 Longevity Workshop report is out! Read how leaders from Massachusetts Institute of Technology (MIT), Stanford Medicine, Anthropic and more explored paths to progress in biotech, tissue replacement, and Healthcare 3.0. Full report: foresight.pub/longevity-repo…

E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains. 1/N 🧵

Great talks, really exciting progress!

Incredibly excited to push this forward alongside Nathan S. Cheng thinks you should work on aging., Laurence Ion 📍 Viva Frontier Tower george church, Peter H. Diamandis, MD, Tim Urban, Kristen Fortney, Celine Halioua, Andrew Steele, Adam Bataineh MD, Derya Unutmaz, MD , Matt Kaeberlein, Chris Mirabile, Geoffrey Miller, Robin Hanson

1/🚀 Excited to share RegVelo, our new computational model combining RNA velocity with gene regulatory network (GRN) dynamics to model cellular changes and predict in silico perturbations. Here's how it works and why it matters! 🧵👇 biorxiv.org/content/10.110…

In new work led by Aditi Merchant with Samuel King, we prompt engineer Evo to perform function-guided protein design with high experimental success rates, including designs that go beyond natural sequences. We also release SynGenome, the first AI-generated genomics database. 🧵 1/N

One of the remarkable things for me about NeurIPS this year was how quickly the entire AI for Biology community has gone all-in on biological foundation models. Virtual cell models will enable us to predict how cell states will change in response to chemical perturbations.

And here's my keynote address at the conference: The Shape of Progress in the 21st Century - YouTube youtube.com/watch?v=oWikDv…

It took a while to wrestle with my emotions and memories but I finally managed to write my thoughts about Zakir Hussain. Feels strange to call it an obituary. srajagopalan.substack.com/p/zakir

As the year comes to an end, time to review the major breakthroughs in aging research of 2024. I think the top 2024 study was the publication of epigenetic predictors of species lifespan and life-history traits by Prof Steve Horvath et al. Amazing work! 1/4 science.org/doi/10.1126/sc…

Alex on H5N1: marginalrevolution.com/marginalrevolu….

Finishing 2024 with one more research result! We’ve trained small language agents to do hard sci tasks: engineering proteins, manipulating DNA, and working with sci literature in a new library called Aviary. We beat humans and frontier LLMs on these tasks!

Looking for exceptional ML engineers to help us reverse disease at Altos Labs in Bay Area, San Diego or Cambridge UK (also roles for data scientists, computer vision experts) job-boards.greenhouse.io/altoslabs/jobs…

How can we use AI to accelerate research in biology and longevity? AlphaFold2’s ability to predict protein structures points at the potential, now we are inviting leading thinkers in AI and longevity research to explore the next leaps in areas like discovering new drugs and

How can we use AI to bring new scientific breakthroughs in biology and longevity? Together with Vitalism Foundation and Longevity Biotech Fellowship, we are inviting experts in AI, biology and longevity research for a two-day workshop. Join us to explore how AI can accelerate progress in areas like drug

Speaker round-up & final reminder to apply to the AI for Biotech Workshop hosted by Longevity Biotech Fellowship Vitalism Foundation and Foresight Institute at Lighthaven in the Bay Area from May 9 - 10. Confirmed presenters include Jason Kelly Gingko Bioworks Morgan Levine Altos Labs Sam Rodriques FutureHouse

Bravo to ARPA-H for visionary innovation! “Millions of Americans are living with the damage caused by strokes and traumatic brain injuries. Current treatments are not enough. ARPA-H hopes to deploy regenerative medicine to transform the treatment of neurological diseases and

"While the world fixates on Donald Trump’s populist cocktail of reciprocal tariffs and big, beautiful deficits, Javier Milei is delivering a man-made miracle that should gladden the heart of every classical economist and quicken the pulse of all political libertarians." 1/5