The Mansley lab is expanding! Fully funded PhD position (EU/UK) available to study corticosteroid regulation of Na+ transport in the kidney School of Medicine. Interested in learning electrophysiology/CRISPR-Cas9 editing/molecular biology? Apply by 12th Oct bit.ly/2RFW1dj.

Delighted to see our work just out in JASN_News examining AKI and CKD in Patients with Type 2 Diabetes. University of Dundee @palmercn Ewan Pearson Moneeza K Siddiqui jasn.asnjournals.org/content/early/…

💥KDIGO 2020 Clinical Practice Guideline for Diabetes Management in CKD Tweetorial ☄️Comprehensive Care in DM & CKD ☄️Glycemic Monitoring & Targets ☄️Lifestyle Interventions ☄️Anti-glycemic Rx 👉🏽 tinyurl.com/yyth59kn 1/ KDIGO Kidney International #KDIGO

Data published by Scottish renal Registry showing relatively low prevalence: 2% of #COVID19 in RRT patients from first wave. Mortality high 26.7% (dialysis) 29.2% transplant Public Health Scotland SRA Jamie Traynor bmcnephrol.biomedcentral.com/articles/10.11…

Association of Cigarette Smoking With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. dlvr.it/RqydJG

New work from our team with relevance for kidney disease: Increased risk of death associated with reduced eGFR/dialysis is similar for deaths from COVID and other causes: so COVID is simply an amplifier of underlying risk. Organ transplant shows more +ve association with COVID

➡️New preprint from the OpenSAFELY team led by @alexjohnwalker ➡️At the height of wave 1 there was concern about very high rates of AKI among patients with COVID-19 ➡️We looked at the overall number of people with recorded AKI in each month medrxiv.org/content/10.110…

KDIGO is pleased to announce the publication of the 2021 Clinical Practice Guideline on the Management of Blood Pressure in Chronic Kidney Disease. Download the Guideline and Executive Summary: bit.ly/KDIGO-BP-GL. #bloodpressure #ckd

It is highly likely there will be further lockdowns in years to come. Getting the public messaging right is essential to ensure urgent medical care is saught by those who need it. Robert Hunter Nicholas Mills Ahsan Andrew Coull @whitworthce emj.bmj.com/content/early/…

Our new paper in JAMA Internal Medicine: is IV contrast nephrotoxic? Lots of studies say no, but have ⬆️risk of confounding: people who get contrast ≠ people who don't get it. We used a natural experiment to try to overcome this bias jamanetwork.com/journals/jamai… 1/5

Very reassuring long-term data from RCT of early steroid avoidance in low immunological risk kidney transplant recipients on Tac and mmf. Good example of linking a RCT to registry to get long-term outcomes. UK Renal Registry @paulphel marc clancy pubmed.ncbi.nlm.nih.gov/33533901/

Colin Geddes Emily McQuarrie Robert Hunter Longer follow up and more granularity in outcomes but similar findings to Robert Hunter paper: #nephrotic needs more outcome studies pubmed.ncbi.nlm.nih.gov/33615070/

Updated NICE Guidelines on managing CKD are just out - some people might think they’re 100% dull but actually there’s some fascinating updates if you have 1 min & 45 seconds spare to read a summary thread👇 nice.org.uk/guidance/ng203

Finally a bit of good news for NHS workers theguardian.com/science/2021/s…

Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults dlvr.it/SHNKjW

New Perspectives online! Robert Hunter Robert Hunter, Neeraj Dhaun EdinUniCVS and Matt Bailey Matt Bailey discuss the impact of excessive #salt intake on human health go.nature.com/3H1yaws

Was great fun writing this with Matt Bailey and Bean (not on Twitter). I learnt a lot; have summarised a few learning points that may be helpful for clinical practice in a blog post: kidneyfish.net/post/salt-pear….

our paper is now out nature ! nature.com/articles/s4158… a 🧵on the excitement and value of Basic Science, DNA replication and repair, teamwork and collaboration, and the fundamental incompatibility of LEGO and DUPLO 1/n

Exciting EastBio DTP PhD opportunity in my lab investigating corticosteroid-regulated Na+ transport in human distal nephron bit.ly/3TVQXjq. Co-supervisors are the excellent Robert Hunter at EdinUniCVS & Mustafa Elshani 🛡️ at Cellular Medicine, University of St Andrews. Closing date is December 5th. Please share!

New insights from Morag Mansley 🙌 👏🏻funded by Kidney Research UK Edinburgh Kidney Mapping the Transcriptome Underpinning Acute Corticosteroid Action within the Cortical Collecting Duct kidney360.asnjournals.org/content/early/…