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I’m in Montana giving a talk at my undergraduate college

Over 20 years ago, Zuker et al. discovered the mammalian sweet taste receptors Now, an exciting collaboration between our labs Biochemistry & Molecular Biophysics reveals the #cryoEM structure of the human sweet receptor-key to sweet taste perception-online Cell! sciencedirect.com/science/articl…

Wow, wow, wow!!! The structure of human sweetness cell.com/cell/fulltext/…

Why are animal models useful for CNS drug discovery? zendudest.substack.com/p/why-animal-m…

New online! RNA polymerase II transcription compartments — from factories to condensates bit.ly/44osaMv

Everything you need to know about GPCRs in a single figure! open.substack.com/pub/zendudest/…

Wow!! #psychedelics ir.compasspathways.com/News--Events-/…

5-HT2A receptors are localized to post-synaptic densities (not intracellular organelles) #psychedelics sciencedirect.com/science/articl…

CASP is getting cut by NIH... 😢 (Anyone with extra funds wanna help support perhaps the most important competition of the century?) science.org/content/articl…

High-resolution cryo-EM structures of small protein-ligand complexes near the theoretical size limit biorxiv.org/content/10.110… #biorxiv_biophys

Inspired by Michael Eisen I've begun an experiment in open science. We are sharing our ongoing work on psychedelic signaling here: open.substack.com/pub/zendudest/… I've decided to make this 'open' as the experiment are of immediate interest to the field and I'll write them up later.

Online now! Structures of USP7 in active and inactive states bound to DNMT1 revealed by cryo-EM dlvr.it/TLrSPD

a serotonin transporter that inhibits CD8 T cell antitumor immunity by depleting intratumoral serotonin cell.com/cell/fulltext/…

“What are the potencies, efficacies and signaling properties I would like to optimize to create psychedelic-like drugs which are therapeutic and are not psychedelic?” #psychedelic open.substack.com/pub/zendudest/…

I am excited to share our latest work in @Neuron exploring the pharmacology of psychedelics. I am deeply grateful to my PI, Prof. Bryan Roth, BryanRoth, for his exceptional guidance, and to all my co-authors for their valuable collaborations.

EVERYTHING YOU EVER WANTED TO KNOW ABOUT #PSYCHEDELICS AND THINGS YOU NEVER THOUGHT ABOUT! cell.com/neuron/abstrac…

It's finally out! Our "somewhat" thorough study on psychedelic polypharmacology. Congrats to Manish Jain BryanRoth and everyone else involved! sciencedirect.com/science/articl… #psychedelics

Hugely important work from ⁦BryanRoth⁩ that opens new doors (and immensely complicates the picture!) The polypharmacology of psychedelics reveals multiple targets for potential therapeutics: Neuron cell.com/neuron/abstrac…

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