BREAKING: UCSF’s David Julius wins the #BreakthroughPrize in Life Sciences for his groundbreaking work on the neuroscience of pain. Congratulations, David! #UCSFProud ucsf.edu/news/2019/09/4…

Structural insights into TRPM8 inhibition and desensitization science.sciencemag.org/content/early/…

nature.com/articles/s4158…

Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii disq.us/t/3i89xc5

Structure of a temperature-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii that has a unique architecture and 2-fold symmetry. Details @ rdcu.be/bQ07J sobolevskylab.org/structure-of-t… nature.com/articles/s4146… #CryoEM

Mechanism of gating and partial agonist action in the glycine receptor biorxiv.org/content/10.110…

Full length P2X7 structures! Congratulations Steve!!

Full length P2X7 structures by Steven E. Mansoor @craigky PNCC and Alanna! Congrats!

Cryo-EM structure of the mitochondrial protein-import channel TOM complex from Saccharomyces cerevisiae. biorxiv.org/cgi/content/sh… #bioRxiv

AMPA receptor Regulation by TARP

Our first bioRxiv is out: Structure of a BAF-like SWI/SNF complex in association with nucleosome. biorxiv.org/content/10.110… #cryoem #transcription

The structural mechanism of TRP channel temperature gating is uncovered and critically involves membrane lipids. We propose that the temperature sensor is the transmembrane domain. Details@ nature.com/articles/s4159… sobolevskylab.org/structural-bas… cuimc.columbia.edu/news/images-of… @AppuKum74640209

This is Willo. She likes to awoo while she eats. Tonight’s meal was worthy of a gentler, but perhaps more meaningful, second awoo. 13/10

Sweet new fold!

First paper from my lab after entering a new field. Great collaboration with Alan Brown and Susan Dutcher! In this paper we use high-resolution #cryoEM to identify 38 ciliary doublet associated proteins including 33 #microtubule inner proteins (#MIPs) 😎 cell.com/cell/fulltext/…

Video abstract for our new paper with Rui Zhang and Susan Dutcher. So many hours of Skype went into this structure... youtu.be/lz4eVJxHdEQ

Juan Du's lab from Van Andel Institute (VAI) came to visit PNCC for some data collection. They got to work with Harry, another PNCC SPOC, who was able to get them 3 structures in different conformations in 3 days. Productive visit!

"Amgen said it was forced to make some changes to its R&D programming. Like many other companies, it is opting to close out its neuroscience research." biospace.com/article/amgen-…

High Yield Monolayer Graphene Grids for Near-Atomic Resolution Cryo-Electron Microscopy biorxiv.org/cgi/content/sh… #biorxiv_biophys