Today in Cell we report the use of prime editing to correct several mutations that cause alternating hemiplegia of childhood (AHC), a rare and devastating neurodevelopmental disorder, in patient-derived cells and in two mouse models. drive.google.com/file/d/1ibC50t… 1/10

Congrats Ruchita Kothari and the authors on this impactful study that identifies a novel basic science discovery of brain inflammation mechanisms post-stroke but also provides a incredibly exciting translational angle showing how targeting Mrgprb2 can prevent/reverse post-stroke

For innate immune cells, the lack of diverse receptor rearrangements has prevented the study of clonal evolution of the innate immune system in human tissues and tumors. With @satpathology and @caleblareau, I’m delighted to share my PhD work that tackles this challenge:

Interesting to see how palm oil-based high fat diet protected mice from obesity-driven tumorigenesis and immune dysfunction. Wondering if we can see similar effects in non-obese mice with tumors. Thoughts Nick Norwitz ? An exciting example of how diet-based interventions can

Congrats Ruchit Patel, MD on this significant study which elucidates how copy number alterations can guide the classification, prognostication, and treatment of meningiomas, especially those that are recurrent and aggressive.

15 years ago today, patient #1 on Penn Medicine Penn Medicine - Abramson Cancer Center CART19 trial received his first infusion. Then, remarkable things started happening. 2.5 pounds of leukemia was obliterated in the several weeks after infusion. #TCell #tcellrx #Immunotherapy

✔️Touring drummer at 17 ✔️Community college at 25 ✔️Brain cancer at 29 Advocate. Researcher. Co-author. Now I’m finally going back to finish my bachelor’s🎓 Apparently you can do patient-led research without a degree—but I’m getting one anyway. Hoping to graduate by 50.

How biohackers are working to extend the human lifespan and get rich doing it. nyer.cm/HOTr3RV

Lung metastasis and recurrence is mitigated by CAR macrophages, in-situ-generated from mRNA delivered by small extracellular vesicles Nature Communications nature.com/articles/s4146…

Priority Brief: Secretion of a VEGF-Blocking scFv Enhances CAR T-cell Potency brnw.ch/21wUGoy Valentina Supper Mark Leick

Our brain-immune system axis has recently has some fascinating new findings Here is one summarized nature.com/articles/s4159… More here erictopol.substack.com/p/our-brainimm…

New nature The possibility that lithium deficiency is a driver of Alzheimer's disease. Experimental model shows Li depletion impedes amyloid clearance, and repletion in humans could be achieved with low doses nature.com/articles/s4158…

In honor of #NeurosurgeryAwarenessMonth, we're thrilled to highlight how one seed of support can lead to breakthrough innovation in patient care, thanks to the support of NREF Meet Aditya Mittal, a 2022 NREF Medical Student Summer Research Fellowship recipient from the

Optimal Pairing of Binder and Costimulatory Domains Improves Dual CAR T Cell Efficacy - Targeting both CD19 and CD22 with optimally paired signaling domains (CD19 = 4-1BB, CD22= CD28) exhibit superior tumor control #TCell #tcellrx #immunotherapy Jim Riley E. John Wherry

"I think Penn is probably one of the best balanced programs in the country." Hear from Josh Golubovsky as he explains the #neurosurgery resident experience Penn Medicine.

We are seeing CNS activity with: -multiple ADCs (TDXD, HER3-DXD, TDM1, sacituzumab) -BiTEs (tarlatamab) -bispecifics (ivonescimab) -ICI (ipi/nivo) We need to move to a default of including pts with untreated/progressive brain mets in clinical trials starting in phase 1 !