🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

People keep asking me how I went from 143 followers to 150 in just 6 months. Let me tell you it has been a journey. A thread 👇

*Stimulus check hits* Me:

More exciting stuff coming later on how I'm going to drop all these costs. Once I hit the goal of $2 for build+miniprep+sequencing, I am going to attempt to build a genome myself. In particular, I want to build Bacillus subtilis PG10 in a modular fashion (for less than ~8k)

The Boss is Back, Baby. In one month, The Boss Baby: Family Business is coming to theaters and @peacockTV on July 2.

Happy to share that our OrthoRep-driven transcriptional biosensor evolution work is now published in ACS Synthetic Bio. Congrats to Alex Javanpour! pubs.acs.org/doi/10.1021/ac…

Today, we present peCHYRON, a DNA recorder that propagates an unending chain of insertions. Each link contains a randomizable 3-bp “signature” sequence that serves to record a cellular event. The result: temporally-resolved cellular event recording! 1/12 biorxiv.org/cgi/content/sh…

this is INCREDIBLE. Everyone who didn't get me a Christmas gift this year, it's not too late...

New this week! In vivo continuous evolution takes advantage of cycles of rapid mutation, amplification and selection inside living cells @cnb_csic CSIC Beatriz Alvarez Luis Ángel Fernández Chang Liu Haiqi Chen UTSW Science Frances Arnold Rosana go.nature.com/3FXKnCK

I'm excited to announce the release of our hardware-agnostic interface to liquid-handling robots, PyLabRobot. PyLabRobot provides a common language for communicating with different types of robots in Python. Github repo: github.com/pylabrobot/pyl… youtube.com/watch?v=s808Eg…

🍞 >>>>>>>

Sean Leonard Definitely don't put the entire plate including the polystyrene into a blender with some LB, homogenize, and then filter the paste through a Buchner funnel and culture the filtrate... unless...?

aip.scitation.org/doi/10.1063/5.…

ML for bio is fed all the DNA sequences of nature and makes a beautiful glowing enzyme ML for tech is fed all the content from the internet and makes a toxic psycho chatbot As you choose your next career moves remember that you have to live in the world you build

Never forget: the people telling you that fedoras don't look awesome, are people who think you don't deserve to look that good.

WE👏 ARE👏AWARE👏THE👏LOGO👏LOOKS👏LIKE👏A👏BEARDED👏DUDE👏IN👏AN👏ORANGE👏HAT👏 —YOU👏DO👏NOT👏NEED👏TO👏KEEP👏POINTING👏THAT👏OUT👏EVERY👏SINGLE👏DAY👏

New experiment this week for COB... I'm releasing a new software tool + an accompanying essay 🧬 Learn more about *The Interactive Mutation Browser*

Let me show you how to DOUBLE your sequence throughput and read length using this one weird trick. Oxford Nanopore HATES this.

In this work, we bring OrthoRep’s mutation rate up to 10^-4 substitutions per base, allowing us to durably hypermutate and evolve chosen genes in vivo at 1-million times the genomic mutation rate of the host yeast cell. What does this afford? biorxiv.org/content/10.110…

Happy to share the peer-reviewed and updated version of our work on OrthoRep-driven evolution of aaRSs for genetic code expansion with unnatural amino acids. Congrats to Yuichi FURUHATA, a true master bioengineer, on leading this excellent work! nature.com/articles/s4146…