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Analysing genomes sequenced Quadram Institute together with the COVID-19 Genomics UK (COG-UK) Consortium database, to inform Norfolk and Norwich University Hospitals clinicians. With a lot of help from many people, behind each dot there's a small army collecting the data, designing the algorithms...

mbio.asm.org/content/11/3/e… Working with lab alumnus Dapeng Zhang (SLU) we describe novel Ig domains in coronaviruses including the agent of the current pandemic SARS-CoV-2 in mBio.

M m n , mm nn n b n m Azedinha #Padarias #Cafés Outros Av. Corifeu de Azevedo Marques, 25 São Paulo BR yelp.com.br/biz/azedinha-s… Horas Fechado hoje Preço $$

Here we report the discovery of two novel domains likely involved in adhesive interactions found in apicomplexans of the piroplasm lineage: the piroplasm β-strand (PiβS) domain and the Babesia α-helical cell surface (BAHCS) domain. pubmed.ncbi.nlm.nih.gov/32533024/

Happy to share our preprint on the structure of Vipp1 and why we believe Vipp1/PspA/Im30 proteins are ESCRT-III homologues, based on primary, secondary, tertiary and quaternary structural similarities. And my first scientific thread! biorxiv.org/content/10.110…

our work about the first hexameric epoxide hydrolase from Streptomyces sp with @LuBruGonzaga

While the generation of NAD+-derivatives as second messengers in these systems was proposed by us previously, here we identify a novel sensor for this signal: a specialized 7-TPR repeat domain with highly-conserved polar and aromatic residues.

3 core components of these systems: 1) a rapidly-evolving TPR module likely recognizing invading elements fused to a histidine kinase. 2) A solo Receiver domain 3) A 2nd Rec domain fused to diverse effector domains including peptidases, nucleoside phosphorylases, &nucleases. 2/n

Everyone knows of nucleic acid double helices. But many peptide double helices are also made in nature: 2 of the famous ones are shown here. Quiz: What are these, which are some organisms producing them & how are they made?

This prediction has now been tested and confirmed by just published work from Sandra Wolin's lab: pubmed.ncbi.nlm.nih.gov/33357439/

We have finished a huge project studying all Rossmann-like proteins, which comprise 20% of all known 3D proteins structures. We figured out why they are so ubiquitous in nature. All data, papers and more details can be found here: prodata.swmed.edu/rossmann_fold/

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Very proud of my former postdoc mentor, L. Aravind (Aravind group), elected fellow of the American Academy of Microbiology (2022)🔬🦠🧬. One of the most brilliant scientist I've met. Well deserved! 🥂

Very excited to share our preprint on "A centimeter-long bacterium with DNA compartmentalized in membrane-bound organelles" #microbiology #chemosynthesis #CellBiology #bacteria biorxiv.org/content/10.110…

I am sure bioinformatics wizards, especially experts in C programming, like Heng Li, will like this en.algorithmica.org/hpc/

Very happy to see our genome skimming tool Patchwork finally published with GBE (Genome Biology and Evolution)! The software has been developed by @fethalen and Clara Koehne performed the benchmarking 1/2 academic.oup.com/gbe/advance-ar…

In this bioRxiv preprint, we (Kevin Corbett ) present the architecture and activation mechanism of the PARIS antiviral defense system. Thanks to our co-authors, Lisa Liang, Eray Enustun, Ph.D., and Joe Pogliano, for their support in shedding light on this Anti-anti-defense system.🧵

Rejeite a Proposta de Redução do Orçamento da FAPESP! - Assine a petição! chng.it/spLvBqsKQm via Change.org Brasil