We are excited to share our study on the 5'FAD capping of #HCV RNA, which is out today in nature. The work is a close collaboration between my lab and the labs of Jens Bukh (not on twitter) and Troels Scheel ScheelLab. Online at rdcu.be/df8p5 Major points here🧵1/15

📢 PREPRINT ALERT 📢 Clustering cells is a key step in most scRNA-seq analysis workflows. It's hard, and harder with batch effects. Our take on the problem, JOINTLY, use a hybrid linear and non-linear NMF. The non-linearity gives performance, the linearity gives interpretability

As a student we were taught, “no experiments could show chromatin did more than salt,” but now with the amazing Anja Groth 🇺🇦 + Robin Andersson; Alice Wenger, Alva Biran, Nicolas Alcaraz & alboo show pluripotency required balanced epigenetic inheritance! nature.com/articles/s4158…

This will be my (academic) home during the fall. On a sabbatical at the Broad, kindly hosted by Kasper Lage and the Novo Nordisk Foundation center for genomic mechanisms of disease. Looking forward to lots of interactions and awesome science! Reach out if you want to meet up!

Histone inheritance is required for epigenome maintenance and early embryonic development! Out in Nature Genetics tinyurl.com/yc8bexr8 🎊💃.  Thanks Alice Wenger, Alva Biran, Nicolas Alcaraz & alboo for heroic efforts 👏💪 & collaborators Josh Brickman, Robin Andersson . 🧵👇

Two training sessions on communication, led by @AlberichJorda , kick off our final event this afternoon. See our program EVENT VI ▶️bit.ly/3rPZQ59 Learn more about ENHPATHY ▶️ enhpathy.eu Marie Skłodowska-Curie Actions

Congratulations to all our students who have done an excellent work as part of our Horizon Europe 🇪🇺 network over the last 3 years. Our EMBO workshop starting today is a great opportunity to add a new dimension to their scientific careers. #EMBOenhanceropathies Marie Skłodowska-Curie Actions

Come and join us! We are looking to recruit a Research Assistant/Technical Associate I to join our team Summer 2024. This could be an ideal position for someone looking for 2 years of research experience before starting graduate school. Apply: careers.peopleclick.com/careerscp/clie…

🧬Opening for a postdoc in my group @NCMMnews Universitetet i Oslo UiO - Det medisinske fakultet @unioslo_mn to generate deep learning models to enhance JASPAR JASPAR database & UniBind, boosting gene regulation research. Project in collaboration with Anshul Kundaje (anshulkundaje@bluesky), Wyeth Wasserman. Plz share jobbnorge.no/en/available-j…

“Transposable elements contribute to nearly 80% of human-specific candidate cis-regulatory elements in cortical cells” 🧠 …🤯 literally! Amazing dataset 🔥 Congrats to all involved! nature.com/articles/s4158…

An encyclopedia of enhancer-gene regulatory interactions in the human genome x.com/argschwind/sta… Very proud—4 years in the making, huge team effort. This is a paper where the author list cannot convey everyone's incredible contributions. My holiday highlights below: 1/

7 days left to apply for our #postdoc position on RNA modifications at the University of Copenhagen! If you’re interested in combining #CRISPR with #nanopore direct RNA sequencing to explore the role of #RNAmodifications in #RNAdegradation, apply here! employment.ku.dk/all-vacancies/…

A true curiosity-driven journey, fulfilling one of my childhood dreams! The tail loss marks a pivotal evolutionary step towards humans and apes. But how did it happen? rdcu.be/dzTba Itai Yanai Jef Boeke

Sooooo excited to share the first paper from the lab now online Nature Genetics 😀😀😀 Interested in MYC, transcriptional mechanisms and (breast) cancer? Check it out👉rdcu.be/dAAht. Short summary thread 👇

Happy to share our joint work with the Falsig Pedersen group on how the physical microenvironment can drive cells to acquire cancer hallmarks. cell.com/cell-reports/f… . In solid tumors, niches with low pH are common. We show that pancreatic cancer and normal organoids...(1/N)

Check out our latest work, scE2G, for mapping the target genes of enhancers from single cell data! biorxiv.org/content/10.110…. See 🧵 below for highlights Amazing work led by co-first authors maya sheth and Wei-Lin Qiu in a great collaboration with Jesse Engreitz 's lab

🚨Job alert! 🚨 We are hiring a computational postdoc or PhD student focusing on - modeling gene regulation using single cell data - investigating the mechanisms of regulatory genetic variants PhD student: employment.ku.dk/all-vacancies/… Postdoc: employment.ku.dk/faculty/?show=…

Latest from the lab! Led by Xuening He, establishing a framework for interpretation of the motif syntax of regulatory elements and a quantitative model for TF cooperativity. Plenty of cool stuff revealed, including TF redundancy and synergy, and their regulatory roles!