Diabetic nephropathy in another pT1b #kidneycancer pt. Occurs in 8% or 1 of every 12-13 nephrectomy specimen. Easy to miss at low power with H&E. That's why we order PAS in every case. Treat as critical value! Tell urologist to send pt to #nephrology! #onconephrology #renalpath

How does the #kidney filter 1500 liters of blood every day without loosing proteins? Our #cryoET data of kidney tissue by #waffleMethod show that the slit diaphragm, which links #podocytes in the #glomeruli, looks like a fishnet! biorxiv.org/content/10.110…

Honored to receive the "Paper of the Month" award from Uniklinik RWTH AC & RWTH Aachen together with Roman Bülow @LaBOORatory!⚡️📰 Check out the publication on pathomics and next-generation morphometry here: nature.com/articles/s4146…

Happy to announce tRigon (toolbox for integrative (path-)omics analysis)!🛠️ tRigon is an user-friendly R Shiny app enabling exploratory analysis of high-dimensional data including pathomics datasets. Check out the publication here: tinyurl.com/mrjtukzt @LaBOORatory Roman Bülow

tRigon is freely available within the CRAN repository (with over 100k downloads already!) and also accessible through GitLab (git-ce.rwth-aachen.de/labooratory-ai…). Many thanks to Roman Bülow, @LaBOORatory, Costa Lab - @costalab.bsky.social and all other amazing collaborators!

An article published in #BMCBioInformatics presents tRigon: an R package that allows researchers without coding abilities to perform exploratory feature analyses of pathomics and non-pathomics datasets on their own using a variety of hardware. bmcbioinformatics.biomedcentral.com/articles/10.11…

Biomarkers are needed to improve cancer nanomedicine clinical translation Check out our work on identification of tumor tissue / biopsy biomarkers in Nature Biomedical Engineering Thanks AstraZeneca Institute of Macromolecular Chemistry CAS @LaBOORatory Uniklinik RWTH AC RWTH Aachen DFG public | @[email protected] European Research Council (ERC) rdcu.be/dD5UQ

This is terrifying. Not the headline... I'm familiar with the science. No, what's terrifying is how far I had to dig through my news notifications to find this story. What's terrifying is that this headline is not #trending on every social media platform. 1/4

Nature research paper: 3D genomic mapping reveals multifocality of human pancreatic precancers go.nature.com/3QnldUH

Our new bioRxiv in out 💫 We systematically analyzed the relationships between the shape and the protein expression of a single cell in the physiological context of heterogeneous human disease tissues! biorxiv.org/content/10.110… 🧵 1/12

It took more than a DECADE... but finally it’s published!!! It started as a CRAZY idea but after tons of hard work we built it: We hijacked the endogenous secretion systems of Toxoplasma gondii, a brain parasite, to deliver active proteins to neurons 👇 nature.com/articles/s4156…

Excited to share our newest review on AI for digital pathology together with Roman Bülow which was published in Pflugers Archiv - European Journal of Physiology today! @LaBOORatory tinyurl.com/4r9mmpzy

DNA-binding protein-A: a multitool in tubular epithelial cells doi.org/10.1016/j.kint… Original article: doi.org/10.1016/j.kint… Uniklinik RWTH AC RWTH Aachen #KICommentary #AKI #ischemiareperfusioninjury

Large language AI models could make natural language again the universal interface of healthcare. Correspondence from Jakob Nikolas Kather and colleagues TU Dresden nature.com/articles/s4159…

1/17) We are thrilled to share our new paper published in @Jclinicalinvest (rb.gy/i2hwnn) that investigates the effect of the metalloproteinase #ADAMTS12 on perivascular fibroblast activation in #fibrosis led by me and Lars Koch

The 2024 #NobelPrize laureates in physics used tools from physics to construct methods that helped lay the foundation for today’s powerful machine learning. John Hopfield created a structure that can store and reconstruct information. Geoffrey Hinton invented a method that can

The 2024 #NobelPrize laureates in chemistry Demis Hassabis and John Jumper have successfully utilised artificial intelligence to predict the structure of almost all known proteins. In 2020, Hassabis and Jumper presented an AI model called AlphaFold2. With its help, they have

Rewired type I IFN signaling is linked to age-dependent differences in COVID-19 biorxiv.org/cgi/content/sh… #biorxiv_immuno

Why does age make COVID-19 more dangerous? Our latest study shows molecular shifts with age, revealing how changes in immune signaling drive inflammation. doi.org/10.1101/2024.1…

Why does age make COVID-19 more dangerous? Our latest study shows molecular shifts with age, revealing how changes in immune signaling drive enhanced inflammation across the immune cell landscape. biorxiv.org/content/10.110…