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Check out our latest preview article in Cell Cell led by Mike Mitchell PhD students roro + Hannah Yamagata on Kedzierska Lab's work identifying OLAH as a key enzyme that drives COVID-19 and other respiratory viral infections! Paper: cell.com/cell/fulltext/…

Thrilled to share our latest in Nature Nanotechnology Nature Nanotechnology led by Mike Mitchell Postdoc Lulu Xue, Ph.D on a new siloxane lipid nanoparticle platform to enable tissue-specific delivery of mRNA therapeutics! Free access: rdcu.be/dVGko blog.seas.upenn.edu/penns-siloxane…

Delighted to share our work developing an mRNA vaccine for C. difficile, published today in Science Magazine. This study with The Drew Weissman Lab was co-led by two truly amazing scientists: Alexa Sem from the Zackular lab and Mohamad-Gabriel Alameh (now at CHOP Research)! science.org/doi/10.1126/sc…

Excited to share our latest in Nature Biomedical Engineering Nature Biomedical Engineering led by Mike Mitchell Postdoc Xuexiang Han (now Prof at SIBCB) on directed chemical evolution to create next gen mRNA LNP therapeutics + vaccines! Free access: rdcu.be/d07M2 blog.seas.upenn.edu/cooking-up-a-b…

Thrilled to share our recent work out today in nature on an mRNA therapeutic to treat pre-eclampsia! This work has been a true passion project from my time Penn Bioengineering in Mike Mitchell, and I’m excited to continue important research in women’s health! nature.com/articles/s4158…

Check out our latest publication in J. Am. Chem. Soc. led by Mike Mitchell Postdoc Lulu Xue, Ph.D in collaboration with The Drew Weissman Lab Karin Wang on a dendron-like degradable ionizable lipid nanoparticle platform for mRNA delivery to the spleen! Link to study: pubs.acs.org/doi/10.1021/ja…

A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb. go.nature.com/41rTqIw

Nice roundup on CRISPR genome editing The Economist economist.com/leaders/2025/0…

Happy Bob Langer day! Had a blast hosting my former advisor in front of standing room only crowd Penn and having him meet our amazing Penn Bioengineering students. Thanks to the Penn Institute of RNA Innovation and The Drew Weissman Lab for hosting Bob!!

Excited to share our work developing Elastin-based Nanoparticles for Therapeutic delivERy (ENTER), a non-viral protein nanoparticle system for nucleic acid and protein delivery Nature Biotechnology Elliot Chaikof! A 🧵on the iterative process of engineering ENTER and applications (1/17):

CHOP & Penn Medicine have delivered the first-ever personalized gene editing therapy for a patient with CPS1 deficiency, marking a major milestone in the application of CRISPR-based treatments. Learn more about KJ & the future of personalized medicine: ms.spr.ly/6015SZLAx.

Presented at #ASGCT2025: A lipid nanoparticle–delivered base-editing therapy was custom designed for an infant with a ureacycle disorder. The affected infant was treated at approximately 7 and 8 months of age. Read the Brief Report: nej.md/42XF03F Editorial:

Breaking News: A baby with a rare disorder made medical history by receiving the first custom gene-editing treatment. The technique used has the potential to help people with thousands of other uncommon genetic diseases. nyti.ms/4j3xGs8

Let's goooo Kelsey!! 🦉

I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with Walter Isaacson & Christiane Amanpour on Amanpour and Company, airing on PBS tonight at 11 pm ET, and on CNN International earlier today. Pls share! youtube.com/watch?v=8YhJM6…

Super excited to share our recent review in collaboration with ⁦Mike Mitchell⁩ , which is published at Small Methods. We reviewed lipid nanoparticles for delivery of CRISPR gene editing components. Congrats to the first-author Fan and co-authors. onlinelibrary.wiley.com/doi/10.1002/sm…

🚨NEW - In vivo CAR T cell generation to treat cancer and autoimmune disease Capstan Therapeutics direct delivery of mRNA-encoded CARs to CD8+ T cells in mouse & NHP models shows tumor control not only in blood, but also tissue. Immune reset seen at B cell recovery science.org/doi/10.1126/sc…

A new paper discussing the importance of federal, institutional, and programmatic support for physician scientist trainees. The same can easily apply to biomedical trainees. We as a nation need to support the next generation of doctors and researchers! rdcu.be/etaiE

Honored to be inducted into the ⁦⁦National Academy of Inventors⁩ today! Especially fun to celebrate with good friends and fellow inductees ⁦Daniel Siegwart⁩ ⁦Giovanni Traverso⁩ ⁦Ali Khademhosseini⁩! ⁦Rice University⁩ ⁦Biotech Launch Pad⁩!