This is the most original article I've ever read. 🔥🔥🔥 journals.plos.org/ploscompbiol/a…

Very pleased that my “birthday card” for PW Anderson’s paper More is Different is now out in ⁦Cell Systems⁩: More is different with a vengeance. Happy 50th and many returns. cell.com/cell-systems/f…

p-values aren't a problem PCA isn't a problem the real problem: reasoning with data is really hard and highly contextual

Here is a first draft of a little manifesto why biology needs more philosophy: johannesjaeger.eu/blog/all-the-p…. I want to improve it. Feedback very welcome.

At the end of grad school I got very interested in developmental biology. Years later, here's a product of that interest in the context of connecting spatial transcriptomics with mechanical and morphological properties of single cells. biorxiv.org/content/10.110…

In my experience, tearing down work does not promote change nearly as much as an inspirational positive message. Therein lies the difficulty.

Excited to share my first preprint! Together with Vahid Shahrezaei and Philipp Thomas, we developed a stochastic modelling and Bayesian inference framework to identify global mechanisms of transcription regulation from time-resolved scRNA-seq data. 1/n biorxiv.org/content/10.110…

I am excited to share that I will be starting my lab at UCL as part of the LMCB UCL Laboratory for Molecular Cell Biology in 2024. We will be studying how cis-regulatory elements controls cell fate decisions during development. We are recruiting at all levels. Learn more and reach out!

Increasingly I feel that academics self-organise themselves not primarily by 'topic of interest' but rather 'epistemology'. Different fields and subfields have different assumptions about what is useful knowledge and how it is acquired 1/2

Happy to share the main piece of work from my PhD, combining single-cell and machine learning methods to model the dynamics of gene expression in neural development. More details below in James' thread!

Gaining a quantitative understanding of developmental processes requires spatiotemporal perturbations and measurements This can be very challenging in vivo We present an optogenetic in vitro system to gain insight into morphogen patterning dynamics For more see James’ thread

Enjoyed this from Kevin Mitchell & Henry Potter on mechanism & causation in neuroscience Striking how applicable the arguments are to dev bio if substitute dev biol->neurosci; embryo->brain; gene regulation->neural causes; GRN as design constraint contributing to causation etc

After precisely 4 years of grad school, I'm excited to share that the FIRST PEER REVIEWED PAPER FROM MY PHD HAS LANDED! cell.com/cell-systems/f… Indulge me in some back-story. 🧵

🚨The Briscoe lab are hiring! Apply by Oct 9 to: • build custom single-cell technologies to study dev bio • collaborate on projects spanning cancer therapy, immune profiling and neurodegenerative disease • learn valuable skills for academia or industry crick.ac.uk/careers-study/…

Beyond thrilled to share my PhD work, published yesterday in Developmental Cell. We show that both NODAL and BMP signalling are active in the human blastocyst, but NODAL signalling is not required to initiate or maintain the human pluripotent epiblast. 1/10

New preprint -- arxiv.org/abs/2501.19178 Old school math bio treatment of perturbation prediction! #CRISPR #singlecell CC - Relation Lindsay Edwards Dr. Caroline Uhler Hagen Triendl Thomas Gaudelet