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There’s something utterly peculiar about a society that sits on its isolated island, fish rotting, exports demolished, amidst a soaring and avoidable death toll, voting for people who won’t feed kids or pay nurses properly, just clapping. I can’t understand it. #BrexitBritain

Congratulations to our own Ruben Hulswit for obtaining an NWO-XS grant! 🎉 nwo.nl/en/news/twenty…

youtu.be/-H27Kv5duYA 🤯 Recent talk from David Baker Institute for Protein Design , for those that missed it.

Here are some incredible things people are already doing with GPT-4 It’s been less than 3.5 hours 🧵 A thread

Today we're making RF Diffusion, our guided diffusion model for protein design with potential applications in medicine, vaccines & advanced materials, free to use. The software has proven much faster and more capable than prior protein design tools. bakerlab.org/2023/03/30/rf-…

Our study on receptor-triggered opening of an endemic human CoV spike is now out on bioRxiv! Excited and proud to have been able to contribute to this remarkable HKU1 story!

Herpes, HIV, Epstein-Barr and other viruses hang around, causing potential long-term health woes. Should ‘long COVID’ surprise us? Thanks Fred Hutch Cancer Center! #LongCovid #herpes fredhutch.org/en/news/center…

Is it possible to design soluble analogs of integral membrane proteins using deep learning? The answer is yes! In our latest study we've successfully created novel soluble proteins with claudin, rhomboid protease, and GPCR-like topologies. Read more here biorxiv.org/content/10.110…

Our paper on allosteric activation of the human CoV HKU1 spike protein by its essential glycan receptor to yield an exposed RBD is now online available nature. We happy. Time for🍻.

Almost the entire history of X-ray crystallography summarized in 23 minutes by Sir David Stuart — from shipping virus crystals in a matchbox and wooden synchrotron hutches to fragment screening and AlphaFold. youtube.com/watch?v=hQO9k8… Diamond Light Source STRUBIOxford XChem

Looking for an interesting PhD position combining virology and structural biology at our department? Do you want to learn more about coronaviruses and viral evolution? Look no further and join the Bosch group!

Think coronavirus spikes have run out of surprises? Think again. Our latest preprint dives into the highly unusual spikes of marine mammal coronaviruses. biorxiv.org/content/10.110… This #cryoEM study was led by Ruben Hulswit, with key contributions from an amazing team.