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Today we publish a paper in Science Magazine that expands nanopore readings to the proteome: a nanopore-based scanner to read off PROTEINS at the single-molecule level! 🤩 Awesome experiments by postdoc Henry Brinkerhoff of our #CDlab, with MD simulations of AksimentievLab 1/x

Drug combinations can overcome therapy resistance but the number of possible combinations is vast. Today we published @nature a study using pharmacological screens in cancer cell lines and multi-omics analysis to identify effective combinations in defined molecular backgrounds.

Friday show-and-tell: @MVickyMoya's 16-gene FISH for markers of cortical cell types, with exc/inh markers shown separately. How many identifiable layers are there in the neocortex anyway?

Our preprint on asymmetric axonemes of mammalian sperm revealed by FIB-SEM/cryoET: biorxiv.org/content/10.110… Thanks for the support from the Vale lab and Agard lab! This work would not be possible without my amazing collaborators from the Lishko lab and Janelia Research Campus.

Today, the Supreme Court not only reversed nearly 50 years of precedent, it relegated the most intensely personal decision someone can make to the whims of politicians and ideologues—attacking the essential freedoms of millions of Americans.

Hey all, the Chaker-Margot lab is looking to expand! If you know students that may be interested in doing structural biology at BiochimieUdeM in beautiful Montreal, Canada, please share. Join our two person army to work on small GTPases 💚, lncRNAs 🧬and signaling 🚦

Lab leaders wrestle with paucity of postdocs nature.com/articles/d4158…

YouTube is free education. But 99% don’t know the best spots on its virtual campus. Here are the top channels to accelerate your learning:

People are asking me about the origins of and key milestones in the timeline of #bioorthogonal chemistry, so here is a quick summary. 1/n

Richard Feynman's Lectures on Physics are timeless: their main strength is in demonstrating how to reason about physics. You may not know all the lectures are completely online: Volume 1: feynmanlectures.caltech.edu/I_toc.html Volume 2: feynmanlectures.caltech.edu/II_toc.html Volume 3: feynmanlectures.caltech.edu/III_toc.html

Time for a pharmacology tweetorial (of sorts) on one-eyed sheep. It’s an odyssey that began on Idaho ranches in the 1950s and ended over half a century later with the approval of several new cancer drugs for basal cell carcinoma and AML. 1/

Modern alchemy appearing today in Science Magazine : science.org/doi/10.1126/sc… Commentary (thank you Prof. Ye!): science.org/doi/10.1126/sc…

Day 10 of great papers in biology. The story of PCR. "Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase," by Saiki R.K. et al. *** In 1969, Brock & Freeze discovered a bacterium, Thermus aquaticus, in two separate thermal springs: One in

cell.com/cell-reports/f… The first research article of TiLab is out.😃 By employing the recombinant tubulin strategy, we reveal the roles of tubulin isotypes in regulating the activities of enzymes for tubulin tyrosination and microtubule stability.

I was watching Lord of the Rings last night and realized there are many parallels with academia! A thread 🧵👇

How can AAA mechanoenzymes be activated by small molecules? In our latest preprint, we report the discovery of a druggable allosteric site for a chemical activator of the AAA protein VCP, and uncover unexpected mimicry of allosteric regulation by this small molecule.

Preprint here: biorxiv.org/content/10.110…