🔥 A major leap for causal biology: FiCS Perturb-seq enables scalable, cryopreservable CRISPR screens & powers X-Atlas/Orion, the largest Perturb-seq atlas ever (8M cells, 18,903 genes)! This is the infrastructure aging research needs. Thanks to the XairaTherapeutics and

Is psychedelic medicine the next frontier in aging? Psilocybin preserved telomere length, activated SIRT1, and improved fur quality in 19-month-old mice. 🐭 #Geroscience #Psychedelics #Telomeres 🔗 nature.com/articles/s4151…

Pathology, but make it AI-powered. From slide analysis to full diagnostic reports, foundation models like GigaPath & mSTAR are transforming clinical workflows, especially for age-related diseases like cancer. Thanks to FaisalLab Microsoft AI at Meta & Hugging Face . Full

𝗧𝗵𝗲 𝗰𝗼𝘀𝘁 𝗼𝗳 𝗯𝗿𝗮𝗶𝗻 𝗱𝗮𝗺𝗮𝗴𝗲: $𝟭 𝘁𝗿𝗶𝗹𝗹𝗶𝗼𝗻/𝘆𝗲𝗮𝗿 ARPA-H FRONT program aims to change that with a 5-year plan to restore brain function using regenerative science. Hope for 20M+ Americans. A boost for longevity. Respect to all driving this bold

Grateful to have spoken at #BTBA2025 last week! I shared our work on SystemsAge, which utilizes epigenetic biomarkers to quantify system-specific aging. Huge thanks to the organizers for the invitation and to all the brilliant minds shaping the future of longevity and

🔥 What if inflammaging isn’t universal—but industrialized? New Nature Aging study finds no inflammaging in the Tsimane and Orang Asli, challenging a core aging biomarker. 📖 nature.com/articles/s4358… #Longevity #Aging #Inflammaging #Geroscience #Microbiome

🐶 This isn’t your average pet med. Loyal spent 553 days designing a study to prove their drug can extend lifespan — not just treat disease. Now the FDA says, “Let’s see it.” Could dogs help crack the aging? 🔗 loyal.com/posts/loyals-l… #Longevity #Aging #DogHealth

What if your tissues age at different speeds — and some fight back? 🧬 This epic DNA methylation atlas (17 tissues, 15K+ samples) reveals that NAD+ salvage pathways show resilience to aging, while PCDHG & HOX drive aging modules. 📄 biorxiv.org/content/10.110… 👋 Thanks Macsue Jacques,

What if your worst sleep habits are driven by your “mental clock” — not your biological one? 🕰️ This study introduces a 3-clock model (bio, social, mental) and shows how students self-sabotage their sleep with bedtime procrastination. 🔗 mdpi.com/2624-5175/7/3/…

🎧 Ep10 of Decoding Longevity drops TOMORROW! Iman Azimi joins us to discuss senolytics & why aging cells aren’t all the same. His new study using single-cell imaging challenges how we target senescence. Hosts: Raghav "RV" Sehgal & Macsue Jacques #Longevity #Senolytics #AgingScience

What if aging isn’t a smooth decline—but a cellular rebellion? 🧬 Our latest episode breaks open the mystery of senescent cells and what it means for aging science. 🎧 Ep10 of #DecodingLongevity is now live! → Watch the full episode on Spotify or YouTube #Longevity #Senolytics

🧠 Your brain may have aged faster during the pandemic, even without COVID-19 infection. A UK Biobank study shows pandemic-era stressors accelerated brain aging by ~5.5 months, especially in older men and those from deprived backgrounds. 👏 Thanks to Ali-Reza Mohammadi-Nejad , Gisli Jenkins and

Shocking but true: your favorite AI model might just be a fancy “no change” predictor. Deep learning models failed to beat additive or linear baselines in predicting gene expression from perturbations. Implications for aging & precision medicine are huge. 📖