How do the #genome, #epigenome & #transcriptome co-evolve in colorectal #cancer? In the 1st of 2 studies in nature we measure the contribution of #chromatin accessibility in #cancer #evolution. #genetics and #epigenetics interplay! #EPICC1 Trevor Graham nature.com/articles/s4158…

How do the #genome, #epigenome and #transcriptome co-evolve in colorectal #cancer? In the second of two papers in @nature, we find gene expr is not strongly heritable & evaluate "driverness" of muts directly in patient tumours nature.com/articles/s4158… Andrea Sottoriva #EPICC2 1/7

Fantastic to see the elegant work of colleagues Trevor Graham and Andrea Sottoriva and their labs unpicking the fundamental mechanisms of fitness in cancer encoded by the epigenome and mutations in colorectal cancer. doi.org/10.1038/s41586… and doi.org/10.1038/s41586…

Spatial transcriptomics meets complex analysis – our new method Belayer models spatial gene expression in layered tissues, now published in Cell Systems. Work led by Cong Ma and Uthsav Chitra with Shirley Zhang. 1/6 authors.elsevier.com/a/1fxla8YyDfj7…

Everyone, including women themselves, should celebrate women in science — today, and every day #8MarchWomensDay #WomenInSTEM #WomenInScience #WomenInMedicine #WomeninEngineering #InternationalWomansDay nature.com/articles/d4158…

🎉🎉🎉Carlos will receive this year's Fondation ARC Leopold Griffuel Award, the most important prize in #CancerResearch in Europe! Amazing recognition of the contributions from all members of the lab and patients over the past 26 years! 🥹🥰 #bcsm Cancer Research UK CRUK Cambridge Institute Cambridge University

Our Mathematical and Computational Methods in Cancer and Biology Symposium has started. Thank you to our opening speakers: Simon Tavaré, Jeannette Wing, Michael Waterman, and Anil Rustgi.

Hearing fantastic science arising from the enormous influence of Simon Tavaré in cancer biology Columbia - Irving Institute for Cancer Dynamics

The lab is hiring, space for a postdoctoral fellow in an exciting new drug development field, G4-quadruplex biology and cancer. Our team is multidisciplinary and recently funded to work on the mechanisms of G4 biology and the non-coding genome in cancer. ubc.wd10.myworkdayjobs.com/en-US/ubcfacul…

The lab is hiring a second postdoctoral fellow, in single cell biology and drug resistance in solid cancers. Opportunity to work in a multidisciplinary environment with collaborators in US, UK, Canada. ubc.wd10.myworkdayjobs.com/en-US/ubcfacul…

Benefits of science in Vancouver … lab social afternoons at the beach to discuss science and life. Join us! University of British Columbia BC Cancer BC Cancer Foundation

Congrats @ypp_lab important advance applying Bayesian topic models to parse single cell states in cancer.

Congratulations to my Cambridge colleague Shankar Balasubramanian, his colleagues David Klenerman and Pascal Mayer on the award of a Canada Gairdner International award for their invention of short read massively parallel DNA sequencing. gairdner.org/winners

Seminal advance from the Dan Landau pioneering WGS plasma assays for residual disease detection. Proud to have contributed to this pioneering translational genomics approach to patient management.