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It's TACOS Thursday!!!! Do JAK-Inhibitors have a role as an adjunct to corticosteroids in Acute Severe Ulcerative Colitis? Let's review this important paper changes should change how we manage our highest risk UC patients!dya

**THE PREDICT STUDY** These are the questions the PREDICT-UC group out of Australia sought to address! The first question: Does the initial dosing of IFX in ASUC (5mg/kg vs 10mg/kg) matter? The second question: does shortening the interval between IFX infusions and providing

Management of Ulcerative Colitis in 2025 ▪️Mild/Mod vs Mod/Severe UC ▪️Oral/rectal 5-ASA vs Advanced therapy ▪️Responder vs Non-Responder ▪️How/when to change therapy All slides available below 👇 🔗 scanned.page/p/671d36a59b830 🙏David T. Rubin, MD #ACG2024

Hey everyone! Ever wondered whether print or digital journals are winning the battle in today’s tech-savvy world? Check out our article. Let’s rethink how we access medical knowledge in this digital age. Give it a read and let us know where you stand! link.springer.com/article/10.100…

Can we detect pre-clinical IBD? Interesting study Gastroenterology American Gastroenterological Association (AGA) 🟢 3 population cohorts 🟢 Differing stats than GEM or PREDICTs studies Point: ⬇️ proteins related to barrier fuction + ⬆️ macrophage function --> predict CD ▶️ same theme. gastrojournal.org/article/S0016-…

Love how ⁦UMichGIHep-Fellowship⁩ offers training to international fellows! ⁦Manjeet Goyal⁩ co-lead on the #TACOS trial of TOF in ASUC - spent time with us ⁦Jeffrey Berinstein⁩ ⁦Peter Higgins⁩ Now back to #DrAhuja ⁦AIIMS, New Delhi 🇮🇳⁩ Im proud to call him my friend.

Withdrawal (WD) 💊 in IBD? ✅ blinded RCT in Gut Journal. ▶️IBD in remission --> WD aTNF or not. ▶️All continue IM. ▶️ 1 Endpoint (EP) = clinical remission 🟢1 EP = equal 🟠BUT - trend for endo recurrence in WD group. gut.bmj.com/content/early/…

.Uma Mahadevan is unpacking everything about IBD and pregnancy, including how children born to a parent with Crohn’s disease may have a higher risk of developing IBD than children born to a parent with ulcerative colitis when it comes to IBD in offspring. #CCCongress25

#CCCongress25 keynote Uma Mahadevan: think placenta = immune organ 🔺Small molecules passively cross placenta during organogenesis (1st trimester) -> teratogenic 🔺Monoclonal Ab too large to cross in 1st trim, & cross later actively when Fc receptor develop -> no teratogenic

#CCCongress24 #IBD & Obesity Amanda Johnson, MD 📈20-50% of pts w #IBD are overweight or obese ⬆️ Risk of IBD complications ⬇️ Response to biologic, might need higher IFX level to achieve remission 💉GLP1 agonist ✔️Effective & safe in IBD ✔️May ⬇️ pro-inflam cytokine

⏺️#IBD is global 🌎 disease➡️needs global 🌎 solutions. ⏺️Transcontinental &transethnic comparisons & collaborations are 🔑 ⏺️👇scoping review lays the ground work to address the challenges &grasp the opportunities 🙏🏼 Anuraag Jena Shabari Shenoy #Manasi for driving this

Cirrhosis is a painful condition - Jessica Rubin And a contra-indication to Tylenol it is not Check out the UpToDate chapter on pain in cirrhosis too

Another great initiative, right steps in generating awareness and passion for IBD. Let’s join and learn together!!

Drug positioning in UC. LOTs of talk about this NMA CGH American Gastroenterological Association (AGA) I made a quick image of INDUCTION ▶️OR (L. columns) = effect size. Bigger = better ▶️Range (R. columns) = CIs. Wider = less certainty ▶️color coded by MOA 🟢hope its useful! cghjournal.org/article/S1542-…

A question that has been in mind for a long time: Is there need of print journals in today’s digital world. What kind of media do you prefer for scientific knowledge Springer Nature AJG - The American Journal of Gastroenterology The Lancet BMC PubMed Trending link.springer.com/article/10.100…

🌍 March is Colorectal Cancer Awareness Month! Join us at #EBGIvsCRC as we bring critical insights, support, and hope to our community. Let's spread the word, share stories, and fight against CRC together! 💙 #ColorectalCancerAwareness

Delivered a talk at IBD School program as a faculty. Great initiative by CCF(India) Dr Vandana Midha. Heartfelt thanks to my mentor Dr. Ajit Sood! #IBDAwareness #Ludhiana #CCFIndia #DMCLudhiana

Try to use generic names for #IBD meds in talking to patients - this helps them get used to the generic name, & reduces anxiety in the age of interchangeable biosimilars. Make the name familiar before the switch to biosims. We *don't* need to help pharma with their marketing.

On the eve of #WorldIBSDay, let's raise awareness about a condition that affects millions yet remains misunderstood. Watch, share, and help spread the word. 💚 #IBS #GutHealth #WorldIBSDay2025 Irritable Bowel Syndrome youtu.be/IFWHG1FyiNk?si… via YouTube

New study reveals TPMT & NUDT15 gene variants in North Indians closely resemble those in Caucasians… Key insight for personalized thiopurine therapy in IBD #Genomics #PrecisionMedicine #IBD #India @ Ajit Sood Arshdeep Singh Manjeet Goyal doi.org/10.5217/ir.202…