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CryoET shows cofilactin filaments inside the microtubule lumen biorxiv.org/cgi/content/sh… #biorxiv_cellbio

Happy to share our new preprint: We imaged protrusions of Drosophila cells with cryoET and found filaments in the microtubule lumen. Subtomo-avg and RNAi suggest these are cofilin-bound actin (cofilactin). By @CamillaVenturaS in collab with Stephen Rogers. biorxiv.org/content/10.110…

Excited to share our latest work on bioRxiv! We visualised single molecules of dynein and its cofactors live in the axon. Work by Alex Fellows in collaboration with the Wellcome Sanger Institute (Andrew Basset, Michaela Bruntraeger and Thomas Burgold) biorxiv.org/content/10.110…

So happy to finally be able to share my post-doc work! I just want to say a massive thank you to everyone who has helped/supported me during this project.

#AlphaLink2 goes #ColabFold 😎 Sergey Ovchinnikov #AlphaFold  biorxiv.org/content/10.110… colab.research.google.com/github/Rappsil…

🚨 Registration is open for NeuroBioUK 2023 (15th Sept) 🚨 If you are interested in neuronal and glial cell biology then this is the conference for you! And York is an amazing place to visit. Deadline for talk abstracts 18th August. sites.google.com/sheffield.ac.u…

Javier M. Gonzalez We think it's the third option: three billion years of natural selection is not nearly enough time to sample even one percent of the vast protein universe. There have got to be remarkable —and useful — molecules still out there.

We're excited to share our latest study on how the lysosomal adaptor JIP3 and regulatory protein LIS1 activate dynein-dynactin. Out now on bioRxiv! Work done by Kashish Singh Clinton Lau Giulia Manigrasso in collaboration with Reto Gassmann lab. (1/6) biorxiv.org/content/10.110…

I've loved chatting to Freddy Frischknecht about unusual microtubules in human parasites and we've highlighted a few of our favourite curiosities in this primer (I still can't believe some parasite flagella with a 3+0 arrangement..!) cell.com/current-biolog…

Some simple EM processing tasks can be overly complicated, so I wrote starparser to help me out. Sharing it here in case others find it useful. For example, you can remove particles with specific orientations, among 40+ other command-line options. github.com/sami-chaaban/s…

Happy to share the first pre-print from the lab focusing on a closed conformation of the mammalian gamma-tubulin ring complex! biorxiv.org/content/10.110…

Our work on how the lysosomal adaptor JIP3, and regulator LIS1 activate the dynein motor protein is now out in Science Magazine ! science.org/doi/10.1126/sc… Many thanks to our reviewers and editor for their valuable input.

AI told you so! Sami Chaaban, Giedre Ratkeviciute and I wrote a feature article in The Biochemist, focussing on usage of machine-learning in protein structure prediction: doi.org/10.1042/bio_20…. We hope it's useful for those of you wondering how to use programs such as AlphaFold!

Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial blog.google/technology/ai/…

We're thrilled to share our new preprint: "Evolutionarily Conserved Principles of ESCRT-III-Mediated Membrane Remodeling Revealed by a Two-Subunit Asgard Archaeal System." biorxiv.org/content/10.110…

As we celebrate the PDB, let's also remember the prolific but underrecognized structural biologists who contributed so much to our field, and to us personally as trainees. Scientists like UC San Francisco UCSF Biophysics legend Janet Finer-Moore, with 125 depositions from 1987 to 2024! 🎉🥳

Excited to share that the AlphaFold 3 model code and weights are now available for academic use. Looking forward to seeing what new research this unlocks and how the research community builds on AlphaFold 3 for scientific discoveries github.com/google-deepmin… 1/2

Happy to share the final format of our paper on Asgard ESCRT-III and the evolution of this protein family in eukaryotes! science.org/doi/10.1126/sc…