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Proximity proteomics identifies septin and PAK2 as decisive regulators of actomyosin expulsion of von Willebrand factor dlvr.it/SftHXj

Check out the #septin cover by Sammy El Mansi and Tom Nightingale

The unconventional Myosin-1C augments endothelial secretion of von Willebrand factor by linking contractile actomyosin machinery to the plasma membrane biorxiv.org/content/10.110…

Septins provide microenvironment sensing and cortical actomyosin partitioning in motile amoeboid T lymphocytes dlvr.it/T0xPlF

Myosin-1C augments secretion of von Willebrand factor by linking contractile actomyosin machinery to the plasma membrane ashpublications.org/bloodadvances/…

Zifkos & colleagues found that deleting #PTP1B in ECs ramps up #clot formation by boosting #VWF #exocytosis, shedding light on how blood clots in veins could be better understood and treated at ahajrnls.org/4byqkcG Konstantinos Zifkos @tmuenzel Christophe Dubois Felix Mahfoud

The great escape: a Shigella effector unlocks the septin cage nature.com/articles/s4146…

Happy to share our paper on impact of senescent ECs on neutrophil trafficking, brilliantly led by Loïc Rolas and Monja Stein . Thanks to our funders Wellcome British Heart Foundation and all collaborators 👉link: shorturl.at/JZyDu

Go Sammy El-Mansi ! Good job! IVBM 2024 #vWF #proteomic

We propose that PAK kinase activity acts to limit its own recruitment. In its absence, a hyper recruitment of PAK and PAK binding partners disrupts the excitable signalling pathways that regulate PI3K activation. biorxiv.org/content/10.110…

AI-based imaging of zebrafish Position with Mostowy Lab Matthew Fuchter James Briscoe jobs.lshtm.ac.uk/Vacancy.aspx?r…

#GlasgowNTD was a wonderful symposium from thought-provoking and inspirational speakers! Thoroughly enjoyed by all!