Our group (led by Prof. Douglas Densmore) is #hiring a Research Systems Engineer II to maintain and develop computational tools and manage IT systems for #microfluidics, lab #automation, and #synbio. Check out the post here: bu.silkroad.com/epostings/inde…

The US Department of Defense 🇺🇸 has awarded a $2.3M, three-year grant to BU engineers who will use the funds to provide underserved high school students with access to pioneering biotechnology companies and a crash course in all things synthetic biology. spr.ly/6015JkvPz

We are happy share our #preprint in #bioRxiv (biorxiv.org/cgi/content/sh…) on #GeneExpression by #Promoters with dual #SigmaFactor preference. Our empirically based #AnalyticalModel could guide the design of #SyntheticCircuits with sequence dependent sensitivity and plasticity.

We studied the regulatory mechanisms of #TandemPromoters. We are happy to share the #AnalyticalModel of their dynamics in a #preprint in #bioRxiv (biorxiv.org/cgi/content/sh…). We hope that they can become useful building blocks of #SyntheticCircuits.

Happy to share our study of E. coli 🦠 tandem promoters 🧬! We used #RNAseq, #FlowCytometry, and #biomodels. Our findings on #transcription interference between these promoters may expand the dynamic range of synthetic genes 👩‍🔬. journals.plos.org/ploscompbiol/a…

We have just published a brief audioslides of this work on our laboratory YouTube channel! 📽️🤓(youtube.com/watch?v=DQPCrb…)

New paper alert! Our overview of Cello 2.0 is now available at Nature Protocols! Congrats to Tim Jones, Samuel Oliveira, Chris Myers, Christopher Voigt, and Douglas Densmore Check it out here: nature.com/articles/s4159…

5 libraries are now available, automating genetic circuit design in bacteria and yeast. User-extendable too!

We've streamlined Cello, making it easier to use by updating the UI and integrating it with Synbiohub

Happy to share our latest work published Nature Protocols on Cello 2.0 cellocad.org The new version includes new organism-libraries and the design of genetic circuits for genome integrations. Thanks to Tim Jones, Douglas Densmore Christopher Voigt, and Chris Myers!

#NewNProt for automated design of #geneticcircuits with Cello 2.0, now possible in new organisms and genetic contexts by CIDAR Lab go.nature.com/3tDnrDl

Everyone in the lab would like to extend a massive congratulations to Douglas Densmore for his promotion to full professor!

Do you know that some #Ecoli🦠promoters have preference for both σ70 and σ38? Today in @BBAjournals, we propose a model for them & show that their #GeneExpression can be easily predicted from their #DNASequence🧬! We can used this in #SyntheticCircuits!👩‍🔬doi.org/10.1016/j.bbag…

Our new paper in @NAR_Open shows that the topology of a #GeneNetwork (#Ecoli🦠) affects its dynamics in #GenomeWide stresses! Our findings can be used to develop robust synthetic circuits and models of complex transcriptional programs in large GRNs: doi.org/10.1093/nar/gk…👩‍🔬🧬💻

New paper in @NAR_Open 😊! Supercoiling sensitivity is a key trigger of #GenomeWide responses to cold shock (#Ecoli)! This can be used for temperature sensitivity of synthetic circuits (e.g. in biotech industries) and new models of large GRNs: doi.org/10.1093/nar/gk…

Glad to share our latest publication, where Douglas Densmore and I share our vision about a hardware, wetware, and software co-design environment for the forward engineer of #Microfluidics chips carrying #Synthetic communities to solve real-life problems. spj.sciencemag.org/journals/bdr/2…

Please RT! We are hiring two post-docs to combine engineered biology, microfluidics, and custom electronics. This work would be joint between Profs Douglas Densmore and Rabia Tugce Yazicigil. More information about the position can be found below: cidarlab.org/contact