🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Out now in Annual Reviews! We share our perspective on using human genetics for drug target identification, with examples from our work of the past 10 years, and our framework for building therapeutic hypotheses #OpenTargetsat10 annualreviews.org/content/journa…

Datalog/Database/SQL friends, is this like the writer monad for Datalog? cs.jhu.edu/~jason/papers/…

A week ago, I posted that I was cooking a logical reasoning benchmark as a side project. Now it's finally ready! Introducing 🦓 𝙕𝙚𝙗𝙧𝙖𝙇𝙤𝙜𝙞𝙘, designed for evaluating LLMs with Logic Puzzles. ⬇️ Quick summary: - Each example is a Zebra Puzzle (a type of Logic Grid

Revealing gene function with statistical inference at single-cell resolution nature.com/articles/s4157…

GO annotations are associations between gene products and GO terms. These come with evidence codes indicating the basis for the association, such as experimental evidence, computational prediction, or expert curation of scientific literature.

Excited to share our latest paper, where we describe ITSN1 as a novel risk gene for Parkinson's disease! We found that rare loss-of-function variants are associated with a 10-fold increased odds of PD. As far as we know, this is the largest effect size reported for sporadic PD

Data keeps emerging that suggests GLP-1RAs like #Ozempic curb all sorts of appetites... not just appetite for food. Brief thread on some new findings...

ClusterDE: a post-clustering differential expression (DE) method robust to false-positive inflation caused by double dipping biorxiv.org/content/10.110…

Transformers in single-cell omics: a review and new perspectives nature.com/articles/s4159…

Cancer cell states: Lessons from ten years of single-cell RNA-sequencing of human tumors cell.com/cancer-cell/fu…

🗨️ WANNA TALK TO YOUR CELLS? Try out CellWhisperer – our new multimodal AI that turns single-cell RNA-seq analysis into a conversation. No coding needed, just chat in plain English. Short walkthrough below. Web app & bioRxiv preprint linked in the thread. Let's dive in! (1/9)

"Common pitfalls in drug target Mendelian randomization and how to avoid them" published at BMC Medicine and led by Dipender Gill: link.springer.com/article/10.118…. Have previously re-tweeted, but worth a quick thread:

scplotter provides a set of functions to visualize single-cell sequencing data in an easy and efficient way. github.com/pwwang/scplott…

At the Nextflow summit Evan Floden & Sasha Dagayev demonstrating Seqera AI (seqera.io/ask-ai) for writing Nextflow code that generates DSL2 Nextflow code that actually runs, with a button to run in a sandbox with nf-core test data! Live: youtube.com/watch?v=LkQj1f…

Moving to a World Beyond “p < 0.05” tandfonline.com/doi/full/10.10…

In one of our first "A path towards AGI" posts we discussed Neuro-symbolic systems. Here's a new example of their implementation👇 Neuro-Symbolic Predicates (NSPs) are smart rules that help robots think by combining visual perception (neural) with logical rules (symbolic). With

🦋 for Science Starter packs for genomics, bioinformatics, #Rstats, Nextflow. Moderation lists. Feeds. Let's rebuild the old scitwitter community and keep this place nice. blog.stephenturner.us/p/bluesky-for-… 🧬🖥️🧪

A Review published in Translational Neurodegeneration explores the connection between Parkinson’s disease and abnormal glucose metabolism, focusing on the underlying pathophysiological mechanisms. …alneurodegeneration.biomedcentral.com/articles/10.11…

Parkinson's disease is the second most common neurodegenerative disease. A recent study investigated whether the GLP-1 receptor agonist, exenatide, could slow the rate of progression of Parkinson's disease: hubs.li/Q037XdV-0

1/ You launched a long-running program... And forgot to use screen or tmux. Now you're terrified to close your terminal. I’ve been there. Here’s how to rescue it like a pro.