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When plant cells undergo stress such as high salinity or drought, they produce different kinds of aldehydes. These help in overcoming stress by altering chemical reactions in cells. But the aldehydes can also interfere with their protein translation machinery & cause toxicity 1/n

Sudipta Mondal, PhD Pradeep kumar Sankar's Lab CCMB Your caricature added real spice to the article! Thanks again and all the best for your future endeavours...

phys.org/news/2024-02-m…

It took nearly half a century to identify and fully appreciate the hidden connection between the early work of Paul Berg and Donald Crothers, with their paths intersecting via an achiral bridge in protein biosynthesis Video Credits HeyGen Pradeep kumar

Kicked off #IBS2024 with Sankar's talk on "Chiral checkpoints and its evolutionary implications", setting the stage for an exciting conference ahead. Stay tuned for more groundbreaking science. TIFR Hyderabad Univ of Hyderabad CCMB Sankaranarayanan Rajan

📢 We're hiring! Two positions open for Project Students at our lab. If you're a hard-working and motivated student, passionate about structural biology, we want to hear from you! To know more about us check sankarslab.weebly.com For applying 👇 shorturl.at/grZ04

Shoutout to koushickvenkatesh and Mukul J S | ಮುಕುಲ್ for bagging the Best Oral and Poster Presentation Awards at the 12th RNA Group Meeting! IIT Guwahati Keep shining!💫👏 #Congrats #PhDLife #Awards #Winning

We are bursting with pride to share the news that our alumnus Aravind Penmatsa Aravind Penmatsa has been recognized with the Rashtriya Vigyan Puraskar (Vigyan Yuva) for his outstanding work in the field of Biological Sciences. What an amazing achievement!! CCMB Sankaranarayanan Rajan

Thrilled to share our latest research on the Emergence of Dip2-mediated DAG-based PKC Signalling Axis in Eukaryotes now available on biorxiv! Shoutout to our amazing team!! Sakshi Shambhavi Sudipta Mondal, PhD Sankaranarayanan Rajan #lipid #teamwork

Diacylglycerol (DAG): A simple #lipid with complex roles! 🧬From #membrane shaping to #cellularsignaling, DAG is a key player inside the cell. Our review explores DAG #metabolism and #regulation in yeast models 👉 doi.org/10.1093/femsyr… Sankar's Lab Sankaranarayanan Rajan Biswajit Pal

Discover the fascinating world of #DAGs !! These seemingly simple lipids play crucial role in myriad cellular processes. Our latest review delves into the intricacies of DAG metabolism and regulation in yeast. Sudipta Mondal, PhD Biswajit Pal Sankaranarayanan Rajan CCMB doi.org/10.1093/femsyr…

Many congratulations to Dr. Sankaranarayanan Rajan for the Prof N Srinivasan Memorial Lecture Award-2023 by the Bioinformatics and Drug Discovery Society. CSIR, India

2025 kicks off with a great start, this time on synthetases with operational dichotomy, i.e., a metal ion beneficial in one and inhibitor for the other, rooted ~3.5bya. Kudos🎉to the incredible team behind this discovery. jotin gogoi Sankaranarayanan Rajan CCMB shorturl.at/j7nIH

Specific tRNAs add their respective amino acids to a growing protein in cell. There are 20 different enzymes called aminoacyl-tRNA synthases for adding the right amino acid to its tRNA. These enzymes also have an editing domain, to correct mistakes in choosing the amino acid. 1/n

We are back again!✌️ Our latest work in @elife reveals the long-lost evolutionary origin of the DAG-PKC signaling pathway regulated by Dip2! Shoutout to the team behind this breakthrough!👏Sakshi Shambhavi Sudipta Mondal, PhD Siddhesh Kamat Sankaranarayanan Rajan CCMB shorturl.at/cxdKI

A new study from @CCMB_CSIR published in Nature Communications, reveals how two enzymes—AlaRS-Ed and ThrRS-Ed—help cells strike a balance between precision and adaptability during protein synthesis. This remarkable molecular switch dates back ~3.5 billion years, underscoring

✨ Throwback Thursday Alert! ✨🔙 Throwback to a molecular detective story🔬: How a little-known enzyme, DTD, helped decode how cells proofread protein-building blocks and influenced the course of evolution. Read the article here: buff.ly/hXCLvdd