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Fecal incontinence can arise from various mechanisms 🚽 bile acid malabsorption (21%) 🚽 lactose malabsorption (18%) 🚽 small intestinal bacterial overgrowth (14%) 🚽fructose/sorbitol malabsorption (14%) 🚽 anorectal dysfunction (up to 50%) #MedTwitter journals.lww.com/jcge/pages/art…

In high risk non-variceal UGIB, OTSC should be considered over TTS clips as first line (STING-2) - high risk in this study defined as Rockall score ≥7 - OTSC lead to higher successful haemostasis and lower rebleeding rates - no differences in mortality or need for surgery

Medicine is a profession where when the canary in the coal mine dies, administrators just complain: "Why can't we find more resilient canaries?"

The immune response

We don’t advertise or spend a nickel on marketing at costplusdrugs.com The mission is to offer the lowest price we can. It’s all word of mouth. So please tell everyone to check out Mark Cuban Cost Plus Drug Company !

I, like many of you, have been contemplating our predicament since election night. We are in a losing war for our democracy and I'm not sure we collectively know who our true adversary is. It's not the voting blocks...white women, Latinos, Gen X. It's not MAGA. It's not even

Read it slowly. Carefully. They're not even hiding it anymore.

Medicare Advantage plans utilize prior authorization to shift patients off their balance sheet and towards taxpayers. This practice cost $6B to private taxpayers in order to profit shareholders of the largest insurers. We need reform of the Medicare Advantage programs and to

RFK Jr. poses a danger to public health, scientific research, medicine, and health care coverage for millions. He wants to stop parents from protecting their babies from measles and his ideas would welcome the return of polio. I have a lot of questions for his Senate hearing.

Whelan: Specific Carbohydrate Diet has been around for a while but until recently was not well studied. DINE-CD studied SCD vs Mediterranean. Outcomes similar. Technically not an equivalence trial Kevin Whelan

For years, people talked about fixing America’s roads and bridges. President Biden and I are getting it done with our Bipartisan Infrastructure Law.

Not a “landslide”. No mandate.

Vaccines work, actually

New nature A mechanism for why durable weight loss is so difficult: epigenetic memory of fat cells nature.com/articles/s4158… Ferdinand von Meyenn Laura Hinte

TRAIT: A Comprehensive Database for T-cell Receptor-Antigen Interactions biorxiv.org/cgi/content/sh… #biorxiv_immuno

New from the Tan lab: CelloType is an end-to-end method for spatial omics data analysis that uses a deep neural network for concurrent object detection, segmentation and classification and performs with high accuracy on diverse datasets. nature.com/articles/s4159…

Long COVID patients have significantly higher levels of six inflammatory molecules in their blood. This includes Von Willebrand Factor, platelet factor 4, serum amyloid A, α-2-antiplasmin, E-selectin, and platelet endothelial cell adhesion molecule-1. medrxiv.org/content/10.110…

New research describes the depletion of germinal center B cells and IgA+ plasma cells in the GI tracts of people living with #HIV. Read more in Science Immunology: bit.ly/3O30kwp

#SundayRead☕️ Another step towards precision #IBD care 🔺400 IBD pts, 1st line TNFi, f/up 7yrs- LOR ~40% 🧬HLADQA1*05 ⬆️ risk of LOR & immunogenicity to IFX 🧬HLADQA1*03 ⬇️ LOR to ADAL AE ⬆️ w 🚺 sex & IFX + one of the 🧬allele Journal of Crohn's and Colitis Fernando Gomollón pubmed.ncbi.nlm.nih.gov/39570188/

A Novel Heterozygous NFKB2 Variant in a Multiplex Family with Common Variable Immune Deficiency and Autoantibodies … pubmed.ncbi.nlm.nih.gov/39579251/