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Congratulations Taylor Eggertsen!!! We’re so proud of you!

Go Saucerman Group!!! 💰 💰 💰

Very proud of Taylor Eggertsen for publishing his first paper, "Virtual drug screen reveals context-dependent inhibition of cardiomyocyte hypertrophy"! His network model predicts 52 FDA-approved drugs that regulate heart cell growth. bpspubs.onlinelibrary.wiley.com/doi/abs/10.111…

Saucerman Group’s very own Bryana Nycole Harris has co-founded the Society for Black Biomedical Scientists and Engineers at UVA, along with @Syn_Gibbs! Virginia BME UVA_BIMS 🔬🥽🎓 @DiversityUVASOM UVA Engineering

.UVA School of Medicine PhD students @Syn_Gibbs & Bryana Nycole Harris recently established the Society for Black Biomedical Scientists and Engineers, a platform for Black individuals to unite & thrive within the UVA_BIMS 🔬🥽🎓 & Virginia BME graduate programs UVA. bit.ly/3JtBTGA

Join us for the Virginia BME Emerging Leaders in BME Symposium 9/1! Bryana Nycole Harris Saucerman Group will share her latest on systems biology of cardiac regeneration-development.

Look forward to some great poster presentations this week by Bryana Nycole Harris, Kaitlyn Wintruba, and Diego Trafton from the Saucerman Group! Should be a great BMES meeting! BMES

Inviting you to the free virtual Netflux and Logic-based Network Biology Meeting on Jan 16. Talks by trainees using our user-friendly Netflux software and other logic-based methods to simulate networks. Keynote by Jay Humphrey Yale BME. Please RT. docs.google.com/document/d/1ZW…

Come join Saucerman Group to discover drugs for heart failure and regeneration with systems biology! Postdocs UVA CVRC open and free no-GRE PhD app due 12/15 Virginia BME.

Great collaboration led by Shulin and Kyle in McCulloch lab UC San Diego Bioengineering with Philip in my Saucerman Group. We integrated RNAseq and network modeling for a surprise result- the direction of stretch affects the sensitivity of mechanosignaling but not which pathways and genes are sensitive.

One week until the free virtual Netflux and Logic-based Network Biology Meeting 1/16! 12 trainee talks, live demo of our user-friendly Netflux software, and a keynote by Jay Humphrey Yale BME. >100 registered, 80% new to logic modeling. please RT Virginia BME tinyurl.com/netfluxmeet

Happy to share our preprint, "Logic-based modeling of biological networks with Netflux" by Alex Clark @muktichowkwale and team! Our first paper on Netflux, software that enables biologists and students to model biological networks without programming. biorxiv.org/content/10.110…

Happy to share our latest paper, "Logic-based mechanistic machine learning on high-content images reveals how drugs differentially regulate cardiac fibroblasts" PNASNews, led by Anders Nelson and collab with Kristen Naegle Virginia BME! pnas.org/doi/10.1073/pn…

With machine learning AND human learning, scientists uncover the biological cause and effect of fibroblast behaviors after heart attack. Published in PNAS and featured in UVA Today. at.virginia.edu/AMrne2 Saucerman Group Jeff Saucerman Anders R Nelson

Happy to share the latest paper iScience Int by our interdisciplinary UVA Medicine and AstraZeneca team. We identified conserved mechanisms that explain how small molecules induce proliferation of cardiomyocytes. cell.com/iscience/fullt…

Previously, we developed a live-cell assay for human iPSC-derived cardiomyocyte proliferation and identified 30 proliferative compounds. Hits included approved L-type Ca channel blockers and compounds with other diverse targets. But how do they work? jmcc-online.com/article/S0022-…

To identify how they work, we profiled human iPSC-derived cardiomyocytes treated with compounds with diverse targets including Wnt pathway, ALK5, CB1R, and COX1/2. We found conserved transcriptomic and proteomic signatures of cardiomyocyte proliferation. 3/ iScience journal

Network analysis integrated transcriptomics/ proteomics to identify conserved pathways including JNK, PI3K, and VEGFR2. Subsequent mechanistic experiments validated their roles in CM proliferation and a surprising role of inducible VEGFR2 activity that limited endoreplication.

Come meet 6 awesomesauce Saucerman Group lab members AHAMeetings #BCVS2024! Presenting network models and experiments of cardiomyocyte proliferation, hypertrophy, survival, and specification. Virginia BME

Congratulations to Alice Luanpaisanon Saucerman Group on her outstanding Virginia BME PhD proposal! 🎇🫀🎇