Lucas Schirmer Sven Wischnewski (Manie Nothnagel Universitätsmedizin Mannheim Neurologie_Mannheim) and collaborators provide new insights into molecular changes associated with the pathogenesis of inclusion body myositis (IBM) using scRNAseq of patient muscle biopsies👉lmy.de/DmwAI

Excited to share our work on cell type mapping of inflammatory muscle diseases highlighting a selective vulnerability of type 2 fibers in inclusion body myositis with data about potential new drug targets. ⁦Sven Wischnewski⁩ ⁦tom lloyd⁩ nature.com/articles/s4358…

Neue Erkenntnisse und Therapieansätze bei entzündlichen Muskelerkrankungen nachrichten.idw-online.de/2024/06/04/neu…

Happy to share our latest work on single nucleus and spatial transcriptomics in inclusion body myositis! Nature Aging @Schirmerlab nature.com/articles/s4358…

Nature research paper: Senescent glia link mitochondrial dysfunction and lipid accumulation go.nature.com/3Kvvhrj

Proud of the Portuguese Glial Network - Rede Glial Portuguesa+redglial (Adelaide Fernandes+myself) symposium on #MultipleSclerosis from different #glial perspectives,cherry of a superb #FENS2024: #Patrick_Küry,#Mendanha_Falcao,Lucas Schirmer & Alana_Hoffmann (@MironLab) showed us many great actors to know+treat #MS.

Very happy to see this paper out in @NAR_Open !! Congrats to Victor Paton on his first publication, and big thanks to all coauthors and Julio Saez-Rodriguez for the opportunity to co-supervise this work

Nächsten Montag beginnt die letzte Woche der Akademischen Mittagspause 2024! Michael Jendrusch, Kai Melde, Lucas Schirmer, Katharina Clemm und Varun Venkataramani schließen die Veranstaltungsreihen mit spannenden Vorträgen ab! Uni Heidelberg EMBL Heidelberg Universitätsklinikum Heidelberg Universitätsmedizin Mannheim

Bei der akademischen Mittagspause von Health + Life Science Alliance Heidelberg Mannheim ist MCTN-Forscher Prof. Dr. Lucas Schirmer (Lucas Schirmer) mit seinem Vortrag "Entzündung im Nervensystem: Gene, Zellen und neue Therapien" dabei. Am 17.07.24, 13:00-13:30 Uhr in der Peterskirche in Heidelberg.

REVIEW Trends in Immunology Lucas Schirmer Iron scavenging and myeloid cell polarization doi.org/10.1016/j.it.2…

REVIEW Trends in Immunology Lucas Schirmer Iron scavenging and myeloid cell polarization 👉doi.org/10.1016/j.it.2…

Thrilled to feature our latest review on iron scavenging and myeloid cell polarization with a particular focus on multiple sclerosis and functions of iron-loaded macrophages at the rims of chronic active MS lesions. sciencedirect.com/science/articl…

Now out - WebAtlas pipeline for visualizing and processing integrated single cell and spatial transcriptomics data ⁦Nature Methods⁩ ⁦Omer Ali Bayraktar⁩ ⁦Haniffa Lab⁩ ⁦Shila Ghazanfar⁩ ⁦Human Cell Atlas⁩ github.com/haniffalab/web… nature.com/articles/s4159…

WebAtlas for visualising single cell & spatial data online is out: rdcu.be/dRsKu With Muzlifah Haniffa Tong LI 李彤 Dave Horsfall+co, we aimed to open up sc/spatial data to biologists & clinicians without coding experience/infrastructure. Rambling🧵on why this matters

Our work with Lucas Schirmer in multiple sclerosis (MS) is out today in Nature Neuroscience. We investigated lesion progression and cell-cell communication events in MS using snRNA-seq and spatial transcriptomics 🧠 See below ⬇️ nature.com/articles/s4159…

Two fantastic papers were published today in Nature Neuroscience highlighting some major advances in understanding MS using spatial transcriptomics 🧬 I feel very lucky to have the chance to write a News & Views article about them! ⭐️ nature.com/articles/s4159…

And, examining subcortica lesions identified niches such as perivascular spaces, the inflamed lesion rim, and the lesion core that are associated with the glial scar and a cilia-forming astrocyte subtype Celia Lerma Martin Pau Badia i Mompel Saez-Rodriguez Group @Schirmerlab nature.com/articles/s4159…

👏The MCTN congratulates Lucas Schirmer Lucas Schirmer Universitätsmedizin Mannheim Mannheim Center for Translational Neuroscience Uni Heidelberg, who received the Science Award of the German Society of Neurology at the DGN Congress currently taking place in Berlin. 👉lmy.de/xCdWv

Thanks to all lab and division members, mentors and supporters of our research over the past years - I feel immensely proud to have met wonderful people along my path and look very much forward to tackling the scientific questions that lay in front of us! Neurologie_Mannheim Lucas Schirmer

Returning from our annual society meeting with a bunch of new ideas, great catching up with friends and colleagues. Wonderful platform talks about MS and IBM transcriptomics by team members ⁦Tim Trobisch⁩ and ⁦Sven Wischnewski⁩ - well done! dgnvirtualmeeting.org/home/dgn/dgn20…