Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration: biorxiv.org/content/10.110…

How did microtubules adapt to support life across 🐸species at divergent thermal niches? Now online & OA Current Biology Thanks to @elladegaulejac Luca Troman Abin Biswas @CarolynMoores1 Max Planck Institute for Infection Biology Birkbeck, University of London 🙌 Enjoy reading! 👉 cell.com/current-biolog…

Congrats!

📢 The Dormann Lab is looking for a PhD student interested in the molecular mechanisms of neurodegeneration and biomolecular condensation! Interested in one of our research projects on disease-linked RNA-binding proteins? Apply to this fantastic PhD program by February 7 👇

Computational Biophysics and Biochemistry: Faculty Position Opening in the Department of Biophysics and Biochemistry at Yale.

Rejuvenating the inner nuclear membrane? We show that nuclear autophagy proceeds through a lumenal vesicle intermediate and requires the dynamin-like 1 fission machinery. Congrats to Philip Mannino and colleagues @LuskingL Melia Lab nature.com/articles/s4155…

We are excited to announce a tenure-track or tenured faculty position in Computational Biophysics and Biochemistry, exploring the intricate molecular and cellular processes and the complex interactions of their macromolecular components! Apply now at apply.interfolio.com/162132

Very cool!

Congrats!

Enjoying lunch as Spring approaches

My lab has postdoc openings in the following areas: 1) Structural biology and single molecule biophysics; 2) Developing novel genome editing methods; and 3) Protein and RNA engineering. Please share the info with your trainees, and RT please. 🙏 postdocs.yale.edu/yale-postdocto…

we are beyond proud that our Yale MB&B Christian Schlieker undergraduate researcher Sophia graduated as the sole Yale University Colleague '25 graduate with an exceptional distinction in the major! Congrats Sophia for this richly deserved honor!

✨We are looking for a PhD student interested in physical cell bio, imaging 🔬, biochemistry, #Xenopus 🐸 & #microtubules ✨ Join us Max Planck Institute for Infection Biology!

We’ve pioneered a disease-agnostic screening platform for aberrant biomolecular condensates—cellular structures linked to incurable neurological diseases. We screened genes and FDA-approved drugs that modulate disease-relevant nuclear condensates: biorxiv.org/cgi/content/sh…

🔬 Key findings: -RNF26 and ZNF335 protect against harmful protein buildup. -identification of compounds that have potential to counteract toxic condensates. -Links to zinc biology, autophagy, and oxidative stress offer new therapeutic angles.

a genome-wide CRISPR screen revealed strong ties between microcephaly-related genes and aberrant condensates revealing unexpected cellular pathology! Our chemical-genetic platform could accelerate the hunt for treatments for neurodegenerative and neurodevelopmental disorders

New study showing the development of pan-Expansion Microscopy by Morgan, King et al. Yale School of Medicine to reveal the molecular composition and structural plasticity of individual nuclear pore complexes including LINC complex-dependent dilation. hubs.ly/Q03rSGym0

Congrats!!

check out our new paper measuring intracellular forces: Nodal modulator (NOMO) is a force-bearing transmembrane protein contributing to a dynamic network of organelle-shaping proteins rupress.org/jcb/article/22…

we suggest that multiple, weak ER spacer interactions create a system that is sufficiently dynamic to allow for secretion and passage of bulky cargo, yet avidity effects support organelle integrity and force buffering