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I'm proud to share our review on some of the lesser studied #GPCR, out now in British Journal of Pharmacology (BJP)! Congrats and thanks to Laura Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, @LiebscherLab, Alessandro Nicoli, TasteLabHUJI, Lior Peri, Hannes Schihada, PhD and Schulte lab bpspubs.onlinelibrary.wiley.com/doi/10.1111/bp…

The May 2024 issue of Cell Press Trends in Pharmacological Sciences is online now. cell.com/trends/pharmac… On the cover: Frizzled protein dynamics Schulte lab Lukas Grätz Pawel Kozielewicz Magdalena M. Scharf Jan H Voss

Our recent paper on FZD-DVL biosensors revealing intriguing differences between Frizzled paralogs was published in ACS Sensors. It was spearheaded by Lukas Grätz and Jan H Voss . Enjoy the read. ACS Sensors pubs.acs.org/doi/10.1021/ac…

Congratulations to Jens Juul Holst who received the 2024 Ulf von Euler lectureship award. An exciting awardee in an outstanding field of science! news.ki.se/this-years-ulf…

Schulte lab Karolinska Institutet, Ogün Adebali determine the structure of inactive FZD7 and compare it with the G-protein-bound form. They refine the FZD activation mechanisms and identify a water pocket and an allosteric cholesterol binding site. nature.com/articles/s4146…

Check this out: 75th birthday issue of Pharmacological Revies and the Dept of Physiology & Pharmacology at Karolinska Institutet pharmrev.aspetjournals.org/content/76/6

Interested in doing a #PhD in the field of #cellbiology and #pharmcology? We have an open PhD student position and develop novel optical to investigate how heterotrimeric #Gproteins enable #GPCR-specific signaling. Please repost :) stellenangebote.uni-marburg.de/jobposting/646…

Orphan GPCR GPR61 is frequently mutated in severe obesity. We have characterized these mutations in molpharm.aspetjournals.org/article/S0026-…

New paper out on the binding modes of a small molecule inverse agonist and the mambaquaretin toxin to the vasopressin V2 receptor. Thanks Sebastien Granier and Bernard Moulliac to have us contribute. Julien Bous and Aurelien Fouillen spearheaded the work. nature.com/articles/s4146…

Outstanding work by Jan H Voss was just published. Different WNTs act differently even though they engage FZDs and LRP5/6. Receptor-receptor association is not necessarily followed by higher order clustering. davide calebiro Yining Yan Lukas Grätz nature.com/articles/s4146…